C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: membrane associated guanylate kinase, WW and PDZ domain containing 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000187391 MAGI2 9606 - 7:78017057-79453574 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000354212 MAGI2-001 78017076-79453574 protein_coding
  ENST00000419488 MAGI2-002 78017076-79453555 protein_coding
  ENST00000517762 MAGI2-008 78518522-78521647 processed_transcript
  ENST00000519748 MAGI2-004 78078383-78490020 retained_intron
  ENST00000520379 MAGI2-005 78185505-78490001 retained_intron
  ENST00000522342 MAGI2-009 78158207-78178067 processed_transcript
  ENST00000522391 MAGI2-003 78019539-79453470 protein_coding
  ENST00000524268 MAGI2-007 78159799-78167973 retained_intron
  ENST00000524316 MAGI2-006 78178036-78197856 processed_transcript
  ENST00000535697 MAGI2-201 78017057-78627242 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonLiverLungMuscleOvaryPlacentaTestisENST00000354212ENST00000419488ENST00000520379ENST00000522391ENST00000535697
Transcript ID Bladder Brain Breast Colon Liver Lung Muscle Ovary Placenta Testis
ENST00000354212 1.229±0.00 N/A 0.710±0.00 0.800±0.21 1.329±0.00 N/A N/A N/A N/A N/A
ENST00000419488 N/A N/A N/A N/A N/A N/A N/A N/A 0.209±0.00 0.995±0.00
ENST00000520379 N/A N/A N/A N/A N/A N/A 1.119±0.00 N/A N/A N/A
ENST00000522391 N/A 2.918±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000535697 N/A 5.672±0.00 1.498±0.00 1.104±0.00 N/A 1.411±0.00 0.677±0.00 0.597±0.00 0.211±0.00 1.540±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008S6 CIL_0008S6_0001 VISTA 7:77922679-78523685

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002092 IDA positive regulation of receptor internalization
GO:0003402 NAS planar cell polarity pathway involved in axis elongation
GO:0004871 IEA signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005770 ISS late endosome
GO:0005886 IDA plasma membrane
GO:0005923 IDA tight junction
GO:0007165 IEA signal transduction
GO:0008285 ISS negative regulation of cell proliferation
GO:0010976 ISS positive regulation of neuron projection development
GO:0014069 ISS postsynaptic density
GO:0016482 ISS cytoplasmic transport
GO:0019902 IPI phosphatase binding
GO:0030159 IDA receptor signaling complex scaffold activity
GO:0030336 ISS negative regulation of cell migration
GO:0030425 ISS dendrite
GO:0031697 IPI beta-1 adrenergic receptor binding
GO:0032516 IDA positive regulation of phosphoprotein phosphatase activity
GO:0032926 ISS negative regulation of activin receptor signaling pathway
GO:0036057 ISS slit diaphragm
GO:0038180 ISS nerve growth factor signaling pathway
GO:0043113 ISS receptor clustering
GO:0043234 ISS protein complex
GO:0045202 ISS synapse
GO:0046332 ISS SMAD binding
GO:0048471 ISS perinuclear region of cytoplasm
GO:0051291 ISS protein heterooligomerization
GO:0051898 IDA negative regulation of protein kinase B signaling
GO:0060395 ISS SMAD protein signal transduction
GO:0070699 ISS type II activin receptor binding
GO:0071850 ISS mitotic cell cycle arrest
GO:0072015 ISS glomerular visceral epithelial cell development
GO:1990090 ISS cellular response to nerve growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021590 magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 protein_coding Danio_rerio
ENSDARG00000073769 MAGI2 (2 of 2) membrane associated guanylate kinase, WW and PDZ domain containing 2 protein_coding Danio_rerio
ENSMUSG00000040003 Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 protein_coding Mus_musculus

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