C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SLX4 structure-specific endonuclease subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000188827 SLX4 9606 - 16:3581181-3611598 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000294008 SLX4-001 3581181-3611598 protein_coding
  ENST00000466154 SLX4-003 3595611-3609259 retained_intron
  ENST00000486524 SLX4-002 3600621-3611585 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000294008ENST00000466154ENST00000486524
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000294008 1.015±0.00 1.069±0.00 0.366±0.00 1.349±0.00 0.455±0.29 0.585±0.00 0.242±0.19 0.473±0.39 0.407±0.00 0.380±0.12 0.344±0.19 0.814±0.15 0.687±0.33 7.918±2.54
ENST00000466154 N/A N/A N/A 0.158±0.00 N/A 0.318±0.00 N/A 0.114±0.00 N/A N/A N/A 0.463±0.00 N/A N/A
ENST00000486524 N/A N/A 0.144±0.00 N/A N/A N/A N/A N/A 0.560±0.00 0.396±0.00 0.090±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000AZ CIL_0000AZ_0001 CGP 16:3539033-3611598
CIL_0000AY CIL_0000AY_0001 CGP 16:3581181-3680143

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000724 IMP double-strand break repair via homologous recombination
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0000784 IDA nuclear chromosome, telomeric region
GO:0000790 IDA nuclear chromatin
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006260 IEA DNA replication
GO:0006281 IMP DNA repair
GO:0006289 IMP nucleotide-excision repair
GO:0008047 IDA enzyme activator activity
GO:0008821 IDA crossover junction endodeoxyribonuclease activity
GO:0010792 IMP DNA double-strand break processing involved in repair via single-strand annealing
GO:0017108 IDA 5'-flap endonuclease activity
GO:0030054 IDA cell junction
GO:0033557 IDA Slx1-Slx4 complex
GO:0043085 IDA positive regulation of catalytic activity
GO:0048257 IDA 3'-flap endonuclease activity
GO:0048476 IDA Holliday junction resolvase complex
GO:0070522 IDA ERCC4-ERCC1 complex
GO:0072429 IMP response to intra-S DNA damage checkpoint signaling

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061414 slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) protein_coding Danio_rerio
ENSDARG00000092927 SLX4 (2 of 2) SLX4 structure-specific endonuclease subunit protein_coding Danio_rerio
ENSMUSG00000039738 Slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) protein_coding Mus_musculus

Loading