C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039738 Slx4 10090 - 16:3979105-4003770 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000040790 Slx4-001 3979123-4001680 protein_coding
  ENSMUST00000128980 Slx4-004 3979128-3985519 retained_intron
  ENSMUST00000145706 Slx4-005 3979133-3982204 retained_intron
  ENSMUST00000146569 Slx4-003 3979105-3989106 nonsense_mediated_decay
  ENSMUST00000156542 Slx4-002 3979124-3995718 nonsense_mediated_decay
  ENSMUST00000165830 Slx4-006 3994768-4001252 protein_coding
  ENSMUST00000171658 Slx4-008 4001201-4003752 protein_coding
  ENSMUST00000171762 Slx4-007 4001003-4003770 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000040790ENSMUST00000128980ENSMUST00000145706ENSMUST00000146569ENSMUST00000156542ENSMUST00000171762
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000040790 N/A N/A N/A 5.437±2.47 N/A N/A N/A 1.289±0.00 0.603±0.49 N/A 0.905±0.61 1.254±0.36 0.676±0.00 10.053±0.00
ENSMUST00000128980 N/A 1.603±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000145706 1.659±0.66 2.738±0.35 2.209±0.64 4.388±1.11 3.639±0.51 2.859±0.68 0.582±0.04 4.750±1.47 2.455±1.57 2.255±0.46 0.522±0.00 3.563±0.74 2.835±0.51 22.653±2.69
ENSMUST00000146569 0.993±0.40 1.188±0.19 N/A 1.671±0.51 1.636±0.59 0.680±0.00 0.496±0.11 2.300±0.55 0.425±0.23 1.083±0.00 0.442±0.00 2.386±0.68 1.685±0.66 7.462±1.42
ENSMUST00000156542 1.498±0.69 2.407±0.38 0.506±0.00 4.867±2.75 1.632±0.52 1.232±0.66 N/A 3.073±1.27 0.813±0.60 1.377±0.57 0.357±0.18 3.072±1.07 2.953±1.62 15.686±1.10
ENSMUST00000171762 N/A N/A N/A 4.170±0.00 N/A N/A N/A N/A N/A N/A 2.209±0.00 N/A 7.897±1.14 34.815±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000AZ CIL_0000AZ_0002 CGP 16:3945007-4003770
CIL_0000AY CIL_0000AY_0002 CGP 16:3979105-4040024

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000724 IEA double-strand break repair via homologous recombination
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0000784 IEA nuclear chromosome, telomeric region
GO:0000790 IEA nuclear chromatin
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0006260 IEA DNA replication
GO:0006281 IEA DNA repair
GO:0006289 IEA nucleotide-excision repair
GO:0008047 IEA enzyme activator activity
GO:0008821 IEA crossover junction endodeoxyribonuclease activity
GO:0010792 IEA DNA double-strand break processing involved in repair via single-strand annealing
GO:0017108 IEA 5'-flap endonuclease activity
GO:0030054 IEA cell junction
GO:0033557 IEA Slx1-Slx4 complex
GO:0043085 IEA positive regulation of catalytic activity
GO:0048257 IEA 3'-flap endonuclease activity
GO:0048476 IEA Holliday junction resolvase complex
GO:0070522 IEA ERCC4-ERCC1 complex
GO:0072429 IEA response to intra-S DNA damage checkpoint signaling

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061414 slx4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) protein_coding Danio_rerio
ENSDARG00000092927 SLX4 (2 of 2) SLX4 structure-specific endonuclease subunit protein_coding Danio_rerio
ENSG00000188827 SLX4 SLX4 structure-specific endonuclease subunit protein_coding Homo_sapiens

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