C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, metabotropic 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196277 GRM7 9606 + 3:6770001-7741533 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357716 GRM7-001 6861115-7741511 protein_coding
  ENST00000389335 GRM7-004 6861240-7693686 nonsense_mediated_decay
  ENST00000389336 GRM7-003 6861240-7693686 protein_coding
  ENST00000402647 GRM7-201 7146446-7693670 protein_coding
  ENST00000435689 GRM7-007 6862743-7306652 nonsense_mediated_decay
  ENST00000440923 GRM7-002 6861240-7693686 nonsense_mediated_decay
  ENST00000443259 GRM7-011 6770001-7146656 nonsense_mediated_decay
  ENST00000445087 GRM7-009 7403050-7578490 protein_coding
  ENST00000448328 GRM7-012 6770069-7306609 protein_coding
  ENST00000458641 GRM7-005 7451781-7636441 processed_transcript
  ENST00000461677 GRM7-008 7298577-7415164 retained_intron
  ENST00000463676 GRM7-006 7298683-7682335 retained_intron
  ENST00000467425 GRM7-013 6861115-7693670 nonsense_mediated_decay
  ENST00000471242 GRM7-010 7693633-7694463 processed_transcript
  ENST00000486284 GRM7-015 6861115-7741533 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENST00000357716ENST00000389335ENST00000389336ENST00000402647ENST00000445087ENST00000448328ENST00000458641ENST00000461677ENST00000463676ENST00000486284
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000357716 0.220±0.00 N/A 1.385±0.46 0.044±0.02 0.069±0.00 N/A 0.003±0.00 0.041±0.02 N/A N/A N/A N/A
ENST00000389335 N/A N/A N/A N/A N/A N/A N/A 0.055±0.00 N/A 0.061±0.00 N/A N/A
ENST00000389336 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.016±0.00 N/A
ENST00000402647 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.152±0.04 N/A 0.144±0.00
ENST00000445087 N/A N/A N/A N/A N/A N/A 0.394±0.00 N/A N/A N/A 0.026±0.00 1.409±0.00
ENST00000448328 N/A N/A N/A N/A N/A N/A 0.557±0.00 N/A N/A 0.984±0.00 N/A N/A
ENST00000458641 N/A 0.064±0.00 N/A N/A N/A N/A 0.007±0.00 N/A N/A N/A 0.021±0.00 N/A
ENST00000461677 N/A N/A N/A N/A N/A N/A N/A 1.225±0.00 N/A N/A N/A N/A
ENST00000463676 0.046±0.00 0.037±0.00 0.438±0.00 0.025±0.00 0.025±0.00 0.012±0.00 0.017±0.01 0.157±0.13 0.003±0.00 N/A N/A N/A
ENST00000486284 N/A N/A 1.145±0.31 N/A N/A N/A N/A N/A N/A 0.036±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005RO CIL_0005RO_0001 CGP 3:5187646-7741533
CIL_0003AB CIL_0003AB_0001 CGP 3:6770001-8568125

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001642 IDA group III metabotropic glutamate receptor activity
GO:0001661 IEA conditioned taste aversion
GO:0001662 IEA behavioral fear response
GO:0004930 IEA G-protein coupled receptor activity
GO:0005245 IEA voltage-gated calcium channel activity
GO:0005246 IBA calcium channel regulator activity
GO:0005509 IDA calcium ion binding
GO:0005886 TAS plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0005938 IDA cell cortex
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007194 IDA negative regulation of adenylate cyclase activity
GO:0007196 IDA adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268 IDA synaptic transmission
GO:0007605 IMP sensory perception of sound
GO:0007608 IEA sensory perception of smell
GO:0007613 IEA memory
GO:0007614 IEA short-term memory
GO:0008066 IDA glutamate receptor activity
GO:0008306 IEA associative learning
GO:0010855 IDA adenylate cyclase inhibitor activity
GO:0014050 ISS negative regulation of glutamate secretion
GO:0016021 IEA:IDA integral component of membrane
GO:0016595 IDA glutamate binding
GO:0019226 IEA transmission of nerve impulse
GO:0030165 NAS PDZ domain binding
GO:0030424 ISS axon
GO:0030425 IDA dendrite
GO:0030534 IEA adult behavior
GO:0030818 IDA negative regulation of cAMP biosynthetic process
GO:0031279 IDA regulation of cyclase activity
GO:0032279 ISS asymmetric synapse
GO:0033555 IEA multicellular organismal response to stress
GO:0042734 IBA presynaptic membrane
GO:0043198 ISS dendritic shaft
GO:0043235 IDA receptor complex
GO:0045211 ISS postsynaptic membrane
GO:0048786 ISS presynaptic active zone
GO:0050877 IEA neurological system process
GO:0051966 IBA regulation of synaptic transmission, glutamatergic
GO:0070588 IEA calcium ion transmembrane transport
GO:0070905 IDA serine binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000056755 Grm7 glutamate receptor, metabotropic 7 protein_coding Mus_musculus

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