C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196591 HDAC2 9606 - 6:113933028-114011308 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000368632 HDAC2-003 113940718-113971157 protein_coding
  ENST00000425835 HDAC2-002 113955927-113970878 protein_coding
  ENST00000518690 HDAC2-006 113956674-113970729 protein_coding
  ENST00000518756 HDAC2-016 113953400-113957286 retained_intron
  ENST00000519065 HDAC2-001 113933028-113971285 protein_coding
  ENST00000519108 HDAC2-004 113940718-113970724 protein_coding
  ENST00000520170 HDAC2-013 113959610-113971137 retained_intron
  ENST00000520746 HDAC2-017 113945380-113949323 retained_intron
  ENST00000520895 HDAC2-010 113958662-113971126 protein_coding
  ENST00000521163 HDAC2-015 113956670-113971137 protein_coding
  ENST00000521233 HDAC2-014 113958427-113971136 retained_intron
  ENST00000521610 HDAC2-008 113956119-113970495 protein_coding
  ENST00000522371 HDAC2-012 113956629-114011308 protein_coding
  ENST00000523240 HDAC2-007 113956690-113970710 protein_coding
  ENST00000523334 HDAC2-005 113940718-113956602 retained_intron
  ENST00000523628 HDAC2-011 113956110-113968530 protein_coding
  ENST00000524334 HDAC2-009 113958684-113971139 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000368632ENST00000519065ENST00000519108ENST00000520746ENST00000523334
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000368632 18.694±0.00 15.354±0.00 1.780±0.00 6.184±0.75 7.601±2.56 14.908±0.00 7.167±5.86 14.410±0.00 4.721±1.15 7.739±6.60 14.214±0.00 15.121±7.41 20.241±0.88 27.571±0.00
ENST00000519065 N/A N/A N/A 0.647±0.02 N/A 0.301±0.00 N/A 0.164±0.00 0.261±0.00 N/A N/A N/A N/A N/A
ENST00000519108 3.760±0.00 10.757±0.00 N/A 12.142±0.00 12.278±0.00 15.877±10.40 N/A 8.760±6.32 1.405±0.00 1.512±0.00 1.944±0.00 55.244±46.04 54.001±0.00 71.870±23.64
ENST00000520746 N/A N/A N/A N/A 14.949±0.00 14.005±0.00 N/A 5.215±0.00 13.287±0.00 N/A 4.637±0.00 49.950±0.00 N/A N/A
ENST00000523334 N/A N/A N/A N/A 1.077±0.00 0.798±0.00 N/A N/A N/A 0.902±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007P5 CIL_0007P5_0009 UCNEbase 6:113887002-114451190

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IEA chromatin
GO:0000790 IDA nuclear chromatin
GO:0000792 IEA heterochromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 IEA core promoter binding
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0003682 ISS chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004407 IEA:IDA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005657 IEA replication fork
GO:0005667 IEA transcription factor complex
GO:0005737 TAS cytoplasm
GO:0006338 IC chromatin remodeling
GO:0006344 IMP maintenance of chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IEA protein deacetylation
GO:0007596 TAS blood coagulation
GO:0008134 IPI transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009913 ISS epidermal cell differentiation
GO:0010870 IMP positive regulation of receptor biosynthetic process
GO:0010977 ISS negative regulation of neuron projection development
GO:0016358 ISS dendrite development
GO:0016575 IMP:IEA histone deacetylation
GO:0016580 IDA Sin3 complex
GO:0016581 IDA NuRD complex
GO:0017053 IEA transcriptional repressor complex
GO:0019213 ISS deacetylase activity
GO:0019899 IPI enzyme binding
GO:0021766 IEA hippocampus development
GO:0030182 IEA neuron differentiation
GO:0031072 IEA heat shock protein binding
GO:0031490 IEA chromatin DNA binding
GO:0031492 IDA nucleosomal DNA binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 ISS circadian regulation of gene expression
GO:0032967 IC positive regulation of collagen biosynthetic process
GO:0033558 IMP protein deacetylase activity
GO:0034605 IEA cellular response to heat
GO:0035098 IDA ESC/E(Z) complex
GO:0035851 IEA Krueppel-associated box domain binding
GO:0042220 IEA response to cocaine
GO:0042475 ISS odontogenesis of dentin-containing tooth
GO:0042493 IEA response to drug
GO:0042733 ISS embryonic digit morphogenesis
GO:0043044 IDA ATP-dependent chromatin remodeling
GO:0043066 ISS negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044822 IDA poly(A) RNA binding
GO:0045347 IC negative regulation of MHC class II biosynthetic process
GO:0045786 TAS negative regulation of cell cycle
GO:0045862 IMP positive regulation of proteolysis
GO:0045892 IC negative regulation of transcription, DNA-templated
GO:0045893 IC positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048714 IEA positive regulation of oligodendrocyte differentiation
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896 IEA regulation of protein kinase B signaling
GO:0055013 IEA cardiac muscle cell development
GO:0060044 IEA negative regulation of cardiac muscle cell proliferation
GO:0060297 IEA regulation of sarcomere organization
GO:0060789 ISS hair follicle placode formation
GO:0061029 ISS eyelid development in camera-type eye
GO:0061198 ISS fungiform papilla formation
GO:0070932 ISS histone H3 deacetylation
GO:0070933 ISS histone H4 deacetylation
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0090311 IEA regulation of protein deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)
GO:2001243 IEA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000019777 Hdac2 histone deacetylase 2 protein_coding Mus_musculus

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