C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: histone deacetylase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000519065 HDAC2-001 ENSG00000196591 9606 - 6:113933028-113971285 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainColonKidneyLiverENST00000519065
Transcript ID Brain Colon Kidney Liver
ENST00000519065 0.647±0.02 0.301±0.00 0.164±0.00 0.261±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007P5 CIL_0007P5_0009 UCNEbase 6:113887002-114451190

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IEA chromatin
GO:0000790 IDA nuclear chromatin
GO:0000792 IEA heterochromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 IEA core promoter binding
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0003682 ISS chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004407 IEA:IDA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005657 IEA replication fork
GO:0005667 IEA transcription factor complex
GO:0005737 TAS cytoplasm
GO:0006338 IC chromatin remodeling
GO:0006344 IMP maintenance of chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IEA protein deacetylation
GO:0007596 TAS blood coagulation
GO:0008134 IPI transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009913 ISS epidermal cell differentiation
GO:0010870 IMP positive regulation of receptor biosynthetic process
GO:0010977 ISS negative regulation of neuron projection development
GO:0016358 ISS dendrite development
GO:0016575 IMP:IEA histone deacetylation
GO:0016580 IDA Sin3 complex
GO:0016581 IDA NuRD complex
GO:0017053 IEA transcriptional repressor complex
GO:0019213 ISS deacetylase activity
GO:0019899 IPI enzyme binding
GO:0021766 IEA hippocampus development
GO:0030182 IEA neuron differentiation
GO:0031072 IEA heat shock protein binding
GO:0031490 IEA chromatin DNA binding
GO:0031492 IDA nucleosomal DNA binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 ISS circadian regulation of gene expression
GO:0032967 IC positive regulation of collagen biosynthetic process
GO:0033558 IMP protein deacetylase activity
GO:0034605 IEA cellular response to heat
GO:0035098 IDA ESC/E(Z) complex
GO:0035851 IEA Krueppel-associated box domain binding
GO:0042220 IEA response to cocaine
GO:0042475 ISS odontogenesis of dentin-containing tooth
GO:0042493 IEA response to drug
GO:0042733 ISS embryonic digit morphogenesis
GO:0043044 IDA ATP-dependent chromatin remodeling
GO:0043066 ISS negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044822 IDA poly(A) RNA binding
GO:0045347 IC negative regulation of MHC class II biosynthetic process
GO:0045786 TAS negative regulation of cell cycle
GO:0045862 IMP positive regulation of proteolysis
GO:0045892 IC negative regulation of transcription, DNA-templated
GO:0045893 IC positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048714 IEA positive regulation of oligodendrocyte differentiation
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896 IEA regulation of protein kinase B signaling
GO:0055013 IEA cardiac muscle cell development
GO:0060044 IEA negative regulation of cardiac muscle cell proliferation
GO:0060297 IEA regulation of sarcomere organization
GO:0060789 ISS hair follicle placode formation
GO:0061029 ISS eyelid development in camera-type eye
GO:0061198 ISS fungiform papilla formation
GO:0070932 ISS histone H3 deacetylation
GO:0070933 ISS histone H4 deacetylation
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0090311 IEA regulation of protein deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)
GO:2001243 IEA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000019911 Hdac2-001 protein_coding Mus_musculus 0 2383
ENSMUST00000105510 Hdac2-002 protein_coding Mus_musculus 0 1166
ENSMUST00000128031 Hdac2-003 processed_transcript Mus_musculus 0 556
ENSMUST00000034431 Tmem170-201 protein_coding Mus_musculus 0.000004 60
ENSMUST00000173269 Neu1-002 retained_intron Mus_musculus 0.00001 58

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