C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipase C, gamma 2 (phosphatidylinositol-specific)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197943 PLCG2 9606 + 16:81739097-81962693 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359376 PLCG2-201 81785990-81958020 protein_coding
  ENST00000562605 PLCG2-016 81889339-81900780 processed_transcript
  ENST00000563193 PLCG2-009 81883269-81898656 protein_coding
  ENST00000563269 PLCG2-012 81931261-81936210 retained_intron
  ENST00000563375 PLCG2-008 81891531-81906384 nonsense_mediated_decay
  ENST00000563834 PLCG2-014 81938478-81939962 processed_transcript
  ENST00000564138 PLCG2-001 81779258-81962693 protein_coding
  ENST00000565020 PLCG2-007 81857945-81859269 retained_intron
  ENST00000565054 PLCG2-002 81739097-81859163 protein_coding
  ENST00000565400 PLCG2-005 81798466-81869233 processed_transcript
  ENST00000567356 PLCG2-015 81938628-81956730 retained_intron
  ENST00000567373 PLCG2-013 81937347-81940059 retained_intron
  ENST00000567980 PLCG2-003 81785746-81921610 retained_intron
  ENST00000569523 PLCG2-006 81842720-81869277 processed_transcript
  ENST00000569929 PLCG2-004 81779342-81883591 retained_intron
  ENST00000570196 PLCG2-011 81923415-81928831 retained_intron
  ENST00000570198 PLCG2-010 81895619-81905487 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359376ENST00000563269ENST00000564138ENST00000567356ENST00000567980
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359376 7.048±0.00 17.569±0.00 3.316±0.00 0.632±0.47 3.681±1.48 2.292±0.46 0.655±0.04 6.693±5.13 1.592±0.53 3.709±1.31 0.878±0.00 1.608±0.56 5.055±1.01 1.916±0.68
ENST00000563269 N/A N/A N/A N/A N/A N/A N/A 4.872±0.00 N/A N/A N/A N/A N/A N/A
ENST00000564138 0.981±0.00 6.144±0.00 1.042±0.00 0.155±0.09 1.220±0.00 0.414±0.02 0.098±0.00 0.289±0.00 0.121±0.00 N/A 0.112±0.00 0.312±0.09 0.732±0.00 0.645±0.00
ENST00000567356 N/A N/A N/A 0.744±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 8.869±0.00 N/A
ENST00000567980 N/A N/A N/A N/A N/A 0.716±0.00 N/A N/A N/A N/A 0.108±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003A9 CIL_0003A9_0001 CGP 16:81445170-81962693
CIL_0001Z3 CIL_0001Z3_0001 CGP 16:81739097-82011488

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002316 IEA follicular B cell differentiation
GO:0004435 IEA phosphatidylinositol phospholipase C activity
GO:0004629 TAS phospholipase C activity
GO:0004871 IEA signal transducer activity
GO:0005515 IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006629 IEA lipid metabolic process
GO:0006661 IDA phosphatidylinositol biosynthetic process
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0008081 IEA phosphoric diester hydrolase activity
GO:0009395 IEA phospholipid catabolic process
GO:0010468 IEA regulation of gene expression
GO:0016055 TAS Wnt signaling pathway
GO:0019722 NAS calcium-mediated signaling
GO:0030168 TAS platelet activation
GO:0030183 ISS B cell differentiation
GO:0032237 IEA activation of store-operated calcium channel activity
GO:0032496 IEA response to lipopolysaccharide
GO:0032959 IEA inositol trisphosphate biosynthetic process
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043069 IEA negative regulation of programmed cell death
GO:0043647 TAS inositol phosphate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0050852 ISS T cell receptor signaling pathway
GO:0050853 ISS B cell receptor signaling pathway
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068763 plcg2 phospholipase C, gamma 2 protein_coding Danio_rerio
ENSMUSG00000034330 Plcg2 phospholipase C, gamma 2 protein_coding Mus_musculus

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