C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class II, DR beta 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198502 HLA-DRB5 9606 - 6:32517343-32530287 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374975 HLA-DRB5-001 32517343-32530287 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374975
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374975 20.748±0.00 95.013±0.00 4.939±0.00 8.567±0.00 22.585±0.21 9.241±0.00 27.181±26.70 56.145±54.00 3.992±1.02 130.601±130.29 5.688±1.13 17.197±18.70 40.577±22.40 4.342±3.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PL CIL_0001PL_0007 CGP 6:32439842-32530287
CIL_0001PK CIL_0001PK_0002 CGP 6:32517343-32589848

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0005515 IEA protein binding
GO:0005765 IDA lysosomal membrane
GO:0005886 TAS plasma membrane
GO:0006955 IEA immune response
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IEA membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031295 TAS T cell costimulation
GO:0031902 IDA late endosome membrane
GO:0032588 TAS trans-Golgi network membrane
GO:0042605 ISS peptide antigen binding
GO:0042613 ISS:IEA MHC class II protein complex
GO:0050852 TAS T cell receptor signaling pathway
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041705 si:busm1-228j01.6 si:busm1-228j01.6 protein_coding Danio_rerio
ENSDARG00000053738 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio
ENSDARG00000054921 wu:fd58b11 wu:fd58b11 protein_coding Danio_rerio
ENSDARG00000055447 si:busm1-194e12.12 si:busm1-194e12.12 protein_coding Danio_rerio
ENSDARG00000056330 mhc2dbb major histocompatibility complex class II DBB gene protein_coding Danio_rerio
ENSDARG00000074510 si:busm1-104n07.3 si:busm1-104n07.3 protein_coding Danio_rerio
ENSDARG00000076307 si:zfos-2070c2.3 si:zfos-2070c2.3 protein_coding Danio_rerio
ENSDARG00000079105 mhc2dab major histocompatibility complex class II DAB gene protein_coding Danio_rerio
ENSDARG00000088872 si:busm1-228j01.4 si:busm1-228j01.4 protein_coding Danio_rerio
ENSDARG00000093706 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio
ENSMUSG00000060586 H2-Eb1 histocompatibility 2, class II antigen E beta protein_coding Mus_musculus
ENSMUSG00000067341 H2-Eb2 histocompatibility 2, class II antigen E beta2 protein_coding Mus_musculus

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