C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198909 MAP3K3 9606 + 17:63622415-63696303 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361357 MAP3K3-001 63622442-63696303 protein_coding
  ENST00000361733 MAP3K3-004 63622440-63695105 protein_coding
  ENST00000577395 MAP3K3-005 63622710-63693874 protein_coding
  ENST00000577597 MAP3K3-006 63622710-63693874 nonsense_mediated_decay
  ENST00000577784 MAP3K3-011 63688529-63689692 processed_transcript
  ENST00000577839 MAP3K3-012 63688742-63689997 retained_intron
  ENST00000578622 MAP3K3-009 63688199-63689614 retained_intron
  ENST00000579585 MAP3K3-007 63622415-63695089 protein_coding
  ENST00000581732 MAP3K3-010 63690330-63692367 nonsense_mediated_decay
  ENST00000584573 MAP3K3-002 63622425-63693960 protein_coding
  ENST00000585302 MAP3K3-008 63666986-63688868 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361357ENST00000361733ENST00000577395ENST00000579585ENST00000584573
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361357 N/A 13.529±0.00 N/A 1.413±0.00 N/A N/A 0.881±0.00 N/A N/A 1.979±0.00 N/A 2.898±1.06 N/A 7.443±0.00
ENST00000361733 N/A N/A 0.752±0.00 2.028±0.00 4.636±0.00 0.831±0.00 1.256±0.00 N/A 1.620±0.21 2.485±0.00 2.730±1.02 7.083±0.00 N/A N/A
ENST00000577395 9.625±0.00 N/A 3.168±0.00 1.975±0.70 N/A 4.399±1.68 1.781±0.00 1.551±0.00 1.231±0.00 7.075±0.00 N/A 4.044±0.05 5.227±0.00 11.269±0.00
ENST00000579585 N/A N/A 0.777±0.00 N/A 1.547±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000584573 N/A N/A N/A N/A N/A 1.008±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009B9 CIL_0009B9_0001 VISTA 17:63374232-63977730
CIL_0002QS CIL_0002QS_0001 CGP 17:63600872-63696303
CIL_0003AI CIL_0003AI_0002 CGP 17:63622415-63701172

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0001568 IEA blood vessel development
GO:0004672 IDA:IEA protein kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0035556 IDA intracellular signal transduction
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777 IDA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:1900745 IEA positive regulation of p38MAPK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060348 map3k3 mitogen-activated protein kinase kinase kinase 3 protein_coding Danio_rerio
ENSMUSG00000020700 Map3k3 mitogen-activated protein kinase kinase kinase 3 protein_coding Mus_musculus

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