C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020700 Map3k3 10090 + 11:106084613-106155446 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000002044 Map3k3-001 106084613-106155446 protein_coding
  ENSMUST00000124449 Map3k3-003 106152064-106154140 processed_transcript
  ENSMUST00000129793 Map3k3-002 106151212-106152378 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000002044
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000002044 20.486±5.50 4.974±1.79 14.961±0.40 8.535±4.42 21.613±1.87 6.133±0.00 2.694±0.00 13.619±0.93 4.947±1.72 29.676±0.66 2.009±0.00 13.137±6.84 14.652±9.35 2.292±0.56

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009B9 CIL_0009B9_0002 VISTA 11:105834084-106435839
CIL_0002QS CIL_0002QS_0002 CGP 11:106066061-106155446
CIL_0003AI CIL_0003AI_0003 CGP 11:106084613-106160860

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0001568 IMP blood vessel development
GO:0004672 ISO protein kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0035556 ISO intracellular signal transduction
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777 ISO protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:1900745 IDA positive regulation of p38MAPK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060348 map3k3 mitogen-activated protein kinase kinase kinase 3 protein_coding Danio_rerio
ENSG00000198909 MAP3K3 mitogen-activated protein kinase kinase kinase 3 protein_coding Homo_sapiens

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