C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class II, DO alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000204252 HLA-DOA 9606 - 6:33004178-33009612 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000229829 HLA-DOA-001 33004178-33009612 protein_coding
  ENST00000374813 HLA-DOA-003 33007497-33009579 protein_coding
  ENST00000450833 HLA-DOA-201 33006746-33009560 protein_coding
  ENST00000467465 HLA-DOA-002 33008061-33009582 processed_transcript
  ENST00000485901 HLA-DOA-004 33006801-33008054 retained_intron
  ENST00000490305 HLA-DOA-005 33006607-33007384 processed_transcript
  ENST00000495532 HLA-DOA-006 33007445-33008124 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000229829ENST00000450833ENST00000485901ENST00000490305
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000229829 3.406±0.00 24.164±0.00 0.404±0.00 1.406±1.23 2.667±1.04 0.988±0.00 1.293±0.88 3.232±2.39 0.567±0.21 7.579±2.94 0.202±0.08 2.718±1.97 1.386±0.67 0.721±0.20
ENST00000450833 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.497±0.00 N/A N/A N/A
ENST00000485901 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.610±0.00 N/A N/A
ENST00000490305 N/A N/A N/A 0.811±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PI CIL_0001PI_0002 CGP 6:33004178-33080775

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002587 IDA negative regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0005515 IEA protein binding
GO:0005765 TAS lysosomal membrane
GO:0005768 IEA endosome
GO:0005886 TAS plasma membrane
GO:0006955 IEA immune response
GO:0007165 TAS signal transduction
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019882 IEA antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 IDA MHC class II protein complex binding
GO:0032395 TAS MHC class II receptor activity
GO:0042613 IDA:IEA MHC class II protein complex
GO:0045580 IEA regulation of T cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001832 si:ch1073-403i13.1 si:ch1073-403i13.1 protein_coding Danio_rerio
ENSDARG00000020286 zgc:123107 zgc:123107 protein_coding Danio_rerio
ENSDARG00000031745 si:busm1-266f07.2 si:busm1-266f07.2 protein_coding Danio_rerio
ENSDARG00000053739 si:busm1-160c18.1 si:busm1-160c18.1 protein_coding Danio_rerio
ENSDARG00000055441 si:busm1-48c11.3 si:busm1-48c11.3 protein_coding Danio_rerio
ENSDARG00000070206 si:zfos-2070c2.1 si:zfos-2070c2.1 protein_coding Danio_rerio
ENSDARG00000074816 si:zfos-367g9.1 si:zfos-367g9.1 protein_coding Danio_rerio
ENSDARG00000075932 si:ch73-211l2.3 si:ch73-211l2.3 protein_coding Danio_rerio
ENSDARG00000079593 si:busm1-228j01.5 si:busm1-228j01.5 protein_coding Danio_rerio
ENSDARG00000086294 CU914776.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000024334 H2-Oa histocompatibility 2, O region alpha locus protein_coding Mus_musculus

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