C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class I, G
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000204632 HLA-G 9606 + 6:29826967-29831125 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360323 HLA-G-001 29827821-29831125 protein_coding
  ENST00000376815 HLA-G-006 29827845-29831125 protein_coding
  ENST00000376818 HLA-G-004 29827845-29831125 protein_coding
  ENST00000376828 HLA-G-002 29826967-29831125 protein_coding
  ENST00000428701 HLA-G-201 29826979-29831122 protein_coding
  ENST00000478355 HLA-G-003 29827845-29831125 retained_intron
  ENST00000478519 HLA-G-005 29827845-29831125 nonsense_mediated_decay

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000360323ENST00000376818ENST00000376828ENST00000478355ENST00000478519
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000360323 4.917±0.00 4.793±0.00 N/A N/A 3.770±0.00 1.164±0.97 N/A 1.696±0.00 N/A N/A N/A 1.477±1.36 95.388±22.58 2.966±0.00
ENST00000376818 N/A N/A 0.679±0.00 N/A 1.318±0.00 0.793±0.00 0.144±0.00 1.352±0.00 N/A 0.250±0.00 N/A N/A 22.336±0.00 N/A
ENST00000376828 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.283±0.00
ENST00000478355 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.405±0.03 N/A N/A
ENST00000478519 28.991±0.00 41.989±0.00 N/A 11.996±0.00 24.288±0.00 0.326±0.00 9.130±0.00 11.979±0.00 5.475±0.00 34.706±0.00 4.715±0.00 81.655±0.00 66.856±0.00 3.157±2.17

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000420 CIL_000420_0003 CGP 6:29722775-29831125
CIL_000420 CIL_000420_0002 CGP 6:29826967-29945884

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001916 IEA positive regulation of T cell mediated cytotoxicity
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002666 IMP positive regulation of T cell tolerance induction
GO:0002767 IDA immune response-inhibiting cell surface receptor signaling pathway
GO:0005102 IPI receptor binding
GO:0005515 IEA protein binding
GO:0005886 TAS plasma membrane
GO:0006955 IEA immune response
GO:0006968 TAS cellular defense response
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0030670 TAS phagocytic vesicle membrane
GO:0031901 TAS early endosome membrane
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0042130 IDA negative regulation of T cell proliferation
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 IEA peptide antigen binding
GO:0042612 IEA MHC class I protein complex
GO:0042803 NAS protein homodimerization activity
GO:0045591 IMP positive regulation of regulatory T cell differentiation
GO:0050776 TAS regulation of immune response
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane
GO:2001199 IDA negative regulation of dendritic cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000037334 H2-M1 histocompatibility 2, M region locus 1 protein_coding Mus_musculus
ENSMUSG00000037537 H2-M11 histocompatibility 2, M region locus 11 protein_coding Mus_musculus
ENSMUSG00000067201 H2-M9 histocompatibility 2, M region locus 9 protein_coding Mus_musculus

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