C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: three prime repair exonuclease 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000213689 TREX1 9606 + 3:48465046-48467645 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296443 TREX1-002 48465046-48467645 protein_coding
  ENST00000395677 TREX1-001 48465046-48467645 retained_intron
  ENST00000433541 TREX1-003 48465811-48467645 protein_coding
  ENST00000444177 TREX1-004 48465946-48467643 protein_coding
  ENST00000456089 TREX1-005 48466262-48467645 protein_coding
  ENST00000492235 TREX1-006 48466270-48467433 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000296443ENST00000395677ENST00000433541ENST00000444177ENST00000456089ENST00000492235
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000296443 N/A N/A 0.392±0.00 0.398±0.00 0.850±0.00 N/A 0.395±0.00 0.969±0.00 N/A N/A 0.163±0.00 0.565±0.00 N/A
ENST00000395677 N/A N/A N/A 0.597±0.00 N/A N/A N/A 1.708±0.00 N/A N/A 0.207±0.00 N/A N/A
ENST00000433541 N/A N/A N/A 0.716±0.00 N/A N/A N/A 2.907±0.00 1.257±0.00 5.592±0.00 3.069±0.00 N/A N/A
ENST00000444177 2.651±0.00 N/A N/A 3.585±0.00 4.207±0.00 N/A N/A N/A N/A 6.930±0.00 3.129±0.00 3.637±0.00 5.910±1.37
ENST00000456089 N/A 14.771±0.00 N/A 5.785±0.00 N/A 2.365±1.10 2.496±0.00 1.123±0.00 1.834±0.74 11.034±0.00 6.473±0.00 8.922±0.00 8.878±0.75
ENST00000492235 7.238±0.00 18.642±0.00 N/A 7.144±0.00 6.004±3.59 2.704±1.17 0.601±0.00 N/A 1.154±0.00 5.377±3.59 2.908±0.00 4.453±1.68 10.995±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002UL CIL_0002UL_0001 CGP 3:48446710-48467645

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000738 IEA DNA catabolic process, exonucleolytic
GO:0003676 IEA nucleic acid binding
GO:0003690 IEA double-stranded DNA binding
GO:0003697 TAS single-stranded DNA binding
GO:0004527 IEA exonuclease activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005635 NAS nuclear envelope
GO:0005730 IDA nucleolus
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006259 ISS DNA metabolic process
GO:0006260 NAS DNA replication
GO:0006281 TAS DNA repair
GO:0006298 NAS mismatch repair
GO:0006310 NAS DNA recombination
GO:0008219 IEA cell death
GO:0008296 ISS 3'-5'-exodeoxyribonuclease activity
GO:0008408 IDA 3'-5' exonuclease activity
GO:0008853 IEA exodeoxyribonuclease III activity
GO:0032405 IDA MutLalpha complex binding
GO:0032407 IDA MutSalpha complex binding
GO:0032479 TAS regulation of type I interferon production
GO:0032481 TAS positive regulation of type I interferon production
GO:0032558 IEA adenyl deoxyribonucleotide binding
GO:0035458 IEA cellular response to interferon-beta
GO:0042803 NAS protein homodimerization activity
GO:0045087 TAS innate immune response
GO:0046872 NAS metal ion binding
GO:0090305 IDA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000049734 Trex1 three prime repair exonuclease 1 protein_coding Mus_musculus

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