C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000213949 ITGA1 9606 + 5:52787896-52959210 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282588 ITGA1-001 52787896-52959210 protein_coding
  ENST00000504086 ITGA1-002 52787947-52825210 processed_transcript
  ENST00000504669 ITGA1-003 52901779-52952512 retained_intron
  ENST00000506275 ITGA1-004 52931152-52956491 retained_intron
  ENST00000509049 ITGA1-007 52864971-52882927 processed_transcript
  ENST00000513737 ITGA1-005 52863973-52887891 processed_transcript
  ENST00000514262 ITGA1-006 52863973-52867218 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282588ENST00000504669ENST00000506275
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282588 18.734±0.00 4.327±0.00 1.877±0.00 0.713±0.40 11.733±0.70 13.076±5.39 3.896±2.12 12.067±0.27 9.069±1.78 4.403±0.57 0.569±0.00 2.324±0.89 10.234±3.48 3.044±2.62
ENST00000504669 N/A N/A 3.184±0.00 0.274±0.00 6.088±0.00 5.649±0.00 1.321±0.00 3.815±0.00 6.859±0.00 4.551±0.00 N/A 2.212±0.00 N/A N/A
ENST00000506275 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.828±0.00 N/A 1.416±0.60 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004PM CIL_0004PM_0001 CGP 5:52787896-52959210

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001669 IEA acrosomal vesicle
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005518 TAS collagen binding
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006936 TAS muscle contraction
GO:0007155 IEA cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008305 TAS integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016020 IDA membrane
GO:0019903 IPI protein phosphatase binding
GO:0030198 TAS extracellular matrix organization
GO:0030593 IEA neutrophil chemotaxis
GO:0032516 IDA positive regulation of phosphoprotein phosphatase activity
GO:0034665 IDA integrin alpha1-beta1 complex
GO:0042059 ISS negative regulation of epidermal growth factor receptor signaling pathway
GO:0042311 IEA vasodilation
GO:0043005 IEA neuron projection
GO:0043204 IEA perikaryon
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045121 IEA membrane raft
GO:0045123 IEA cellular extravasation
GO:0045178 IEA basal part of cell
GO:0046872 IEA metal ion binding
GO:0048812 IEA neuron projection morphogenesis
GO:0060326 IEA cell chemotaxis
GO:0070062 IDA extracellular vesicular exosome
GO:0098639 IMP collagen binding involved in cell-matrix adhesion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074316 itga1 integrin, alpha 1 protein_coding Danio_rerio
ENSMUSG00000042284 Itga1 integrin alpha 1 protein_coding Mus_musculus

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