C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adenylosuccinate lyase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000239900 ADSL 9606 + 22:40346500-40369367 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216194 ADSL-017 40346528-40366614 protein_coding
  ENST00000342312 ADSL-002 40346503-40366996 protein_coding
  ENST00000423176 ADSL-009 40364962-40368038 protein_coding
  ENST00000466863 ADSL-003 40346518-40350323 retained_intron
  ENST00000477111 ADSL-005 40346529-40359302 retained_intron
  ENST00000480775 ADSL-006 40358968-40363053 nonsense_mediated_decay
  ENST00000623063 ADSL-001 40346500-40369367 protein_coding
  ENST00000623287 ADSL-012 40346530-40361577 nonsense_mediated_decay
  ENST00000623387 ADSL-015 40364558-40366556 retained_intron
  ENST00000623632 ADSL-010 40346500-40361313 protein_coding
  ENST00000623978 ADSL-011 40346529-40361566 protein_coding
  ENST00000624027 ADSL-016 40364962-40368105 protein_coding
  ENST00000624474 ADSL-013 40346532-40360431 nonsense_mediated_decay
  ENST00000624503 ADSL-007 40346518-40352055 nonsense_mediated_decay
  ENST00000625194 ADSL-014 40354259-40366517 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216194ENST00000342312ENST00000466863ENST00000623063ENST00000623978ENST00000625194
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216194 16.383±0.00 18.919±0.00 12.318±3.23 11.705±5.59 11.212±2.01 6.914±2.89 13.779±8.12 9.330±0.84 N/A 49.453±16.79 30.555±21.33 28.669±0.00 28.718±1.03
ENST00000342312 N/A N/A 7.398±0.00 4.981±0.00 N/A 4.504±0.00 N/A 6.697±0.00 5.185±0.00 18.019±0.00 7.235±0.00 N/A N/A
ENST00000466863 N/A N/A N/A N/A N/A N/A N/A N/A 13.354±0.00 N/A N/A N/A N/A
ENST00000623063 N/A N/A N/A N/A N/A 1.856±0.00 N/A N/A N/A 7.883±3.76 N/A N/A N/A
ENST00000623978 N/A N/A N/A N/A N/A N/A 9.696±0.00 N/A N/A N/A 94.960±0.00 50.986±0.00 N/A
ENST00000625194 N/A 19.975±0.00 N/A N/A 15.712±0.00 9.793±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006F2 CIL_0006F2_0001 CGP 22:40044817-40369367

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0003824 IEA catalytic activity
GO:0004018 IDA:IEA N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006144 TAS purine nucleobase metabolic process
GO:0006163 IEA purine nucleotide metabolic process
GO:0006164 IC purine nucleotide biosynthetic process
GO:0006167 IDA AMP biosynthetic process
GO:0006189 IEA 'de novo' IMP biosynthetic process
GO:0007584 IEA response to nutrient
GO:0008152 IDA metabolic process
GO:0009060 IEA aerobic respiration
GO:0009152 IEA purine ribonucleotide biosynthetic process
GO:0009156 IEA ribonucleoside monophosphate biosynthetic process
GO:0009168 TAS purine ribonucleoside monophosphate biosynthetic process
GO:0014850 IEA response to muscle activity
GO:0042594 IEA response to starvation
GO:0044208 IEA 'de novo' AMP biosynthetic process
GO:0044281 TAS small molecule metabolic process
GO:0051262 IDA protein tetramerization
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0070626 IEA (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017049 adsl adenylosuccinate lyase protein_coding Danio_rerio
ENSMUSG00000022407 Adsl adenylosuccinate lyase protein_coding Mus_musculus

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