C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actin related protein 2/3 complex, subunit 4, 20kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000241553 ARPC4 9606 + 3:9792495-9807726 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000397261 ARPC4-001 9792558-9807726 protein_coding
  ENST00000417500 ARPC4-003 9793082-9806436 nonsense_mediated_decay
  ENST00000433034 ARPC4-010 9793117-9806572 protein_coding
  ENST00000440787 ARPC4-002 9793093-9806417 nonsense_mediated_decay
  ENST00000467289 ARPC4-008 9793095-9804214 retained_intron
  ENST00000479956 ARPC4-004 9793082-9798121 retained_intron
  ENST00000485273 ARPC4-009 9793096-9804013 protein_coding
  ENST00000498623 ARPC4-005 9792495-9806442 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000397261ENST00000433034ENST00000467289ENST00000498623
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000397261 37.950±0.00 23.466±0.00 18.864±0.00 N/A N/A 1.474±0.00 38.109±0.00 N/A 33.210±0.00 21.760±0.00 64.786±0.00 26.114±12.71 N/A
ENST00000433034 N/A N/A N/A N/A N/A N/A 12.716±0.00 N/A N/A 4.285±0.00 45.000±0.00 50.280±8.92 N/A
ENST00000467289 N/A N/A N/A N/A N/A 4.852±0.00 N/A 19.656±0.00 N/A 5.938±0.00 N/A N/A N/A
ENST00000498623 88.641±0.00 N/A 68.185±0.00 81.151±0.00 85.444±0.00 N/A 85.943±0.00 29.185±0.00 78.422±0.00 39.038±0.00 121.145±0.00 N/A 87.629±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WT CIL_0002WT_0001 CGP 3:9757342-9793011
CIL_0002WP CIL_0002WP_0001 CGP 3:9779860-9807726
CIL_0005IQ CIL_0005IQ_0001 CGP 3:9792495-9835401

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005200 IDA structural constituent of cytoskeleton
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0005885 IEA:IDA Arp2/3 protein complex
GO:0015629 IEA actin cytoskeleton
GO:0019899 IPI enzyme binding
GO:0030041 IEA actin filament polymerization
GO:0030674 IPI protein binding, bridging
GO:0034314 IEA:IDA Arp2/3 complex-mediated actin nucleation
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 IEA cell projection
GO:0045010 NAS actin nucleation
GO:0045087 TAS innate immune response
GO:0051015 NAS actin filament binding
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054063 arpc4 actin related protein 2/3 complex, subunit 4 protein_coding Danio_rerio
ENSDARG00000058225 arpc4l actin related protein 2/3 complex, subunit 4, like protein_coding Danio_rerio
ENSMUSG00000079426 Arpc4 actin related protein 2/3 complex, subunit 4 protein_coding Mus_musculus

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