C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: left-right determination factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000243709 LEFTY1 9606 - 1:225886282-225911382 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000272134 LEFTY1-001 225886282-225889146 protein_coding
  ENST00000492457 LEFTY1-002 225887785-225911382 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonKidneyENST00000272134ENST00000492457
Transcript ID Colon Kidney
ENST00000272134 16.169±10.07 N/A
ENST00000492457 N/A 3.529±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007R5 CIL_0007R5_0001 VISTA 1:225466688-226068183
CIL_0005S1 CIL_0005S1_0001 CGP 1:225886282-225924278

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0003007 ISS heart morphogenesis
GO:0005125 IEA cytokine activity
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005615 IEA extracellular space
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007368 ISS determination of left/right symmetry
GO:0008083 IEA growth factor activity
GO:0016049 IEA cell growth
GO:0040007 IEA growth

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019920 lft1 lefty1 protein_coding Danio_rerio
ENSDARG00000044059 lft2 lefty2 protein_coding Danio_rerio
ENSMUSG00000038793 Lefty1 left right determination factor 1 protein_coding Mus_musculus
ENSMUSG00000066652 Lefty2 left-right determination factor 2 protein_coding Mus_musculus

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