C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: left right determination factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000038793 Lefty1 10090 + 1:180935022-180938400 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000037361 Lefty1-001 180935022-180938400 protein_coding
  ENSMUST00000132087 Lefty1-002 180936871-180937810 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000037361ENSMUST00000132087
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000037361 1.833±0.43 2.903±1.59 3.693±2.37 0.087±0.04 1.159±0.50 0.901±0.00 0.520±0.10 0.450±0.10 0.798±1.00 1.167±0.48 0.349±0.17 1.497±0.41 0.403±0.36 0.288±0.11
ENSMUST00000132087 3.504±1.01 9.599±2.86 9.851±0.00 0.498±0.17 3.811±1.17 7.970±1.83 0.717±0.21 1.028±0.35 2.423±2.41 3.347±0.11 0.197±0.00 5.841±1.59 1.217±0.88 0.491±0.18

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005S0 CIL_0005S0_0002 CGP 1:180904274-180938400

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0003007 IMP heart morphogenesis
GO:0005125 IEA cytokine activity
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005576 IDA extracellular region
GO:0005615 IEA extracellular space
GO:0007368 IDA determination of left/right symmetry
GO:0008083 IEA growth factor activity
GO:0008285 IGI negative regulation of cell proliferation
GO:0009948 IGI anterior/posterior axis specification
GO:0016049 IEA cell growth
GO:0032526 IDA response to retinoic acid
GO:0038100 IPI nodal binding
GO:0042074 IGI cell migration involved in gastrulation
GO:1900108 IDA negative regulation of nodal signaling pathway
GO:1900124 IDA negative regulation of nodal receptor complex assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019920 lft1 lefty1 protein_coding Danio_rerio
ENSDARG00000044059 lft2 lefty2 protein_coding Danio_rerio
ENSG00000143768 LEFTY2 left-right determination factor 2 protein_coding Homo_sapiens
ENSG00000243709 LEFTY1 left-right determination factor 1 protein_coding Homo_sapiens

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