C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actinin, alpha 3 (gene/pseudogene)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000248746 ACTN3 9606 + 11:66546395-66563329 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000502692 ACTN3-003 66546395-66563326 protein_coding
  ENST00000511191 ACTN3-005 66546915-66554561 nonsense_mediated_decay
  ENST00000513398 ACTN3-001 66546841-66563329 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENST00000502692ENST00000511191ENST00000513398
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000502692 N/A N/A N/A 0.044±0.00 N/A N/A N/A N/A N/A N/A N/A 0.744±0.21
ENST00000511191 N/A N/A 0.038±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000513398 0.193±0.00 0.233±0.00 N/A 42.552±42.51 0.063±0.00 0.010±0.00 0.151±0.00 0.062±0.03 44.733±20.53 0.145±0.11 0.026±0.00 0.597±0.23

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003779 IEA actin binding
GO:0005178 TAS integrin binding
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005829 TAS cytosol
GO:0005884 TAS actin filament
GO:0005925 IMP focal adhesion
GO:0006936 IEA muscle contraction
GO:0008307 TAS structural constituent of muscle
GO:0030017 IEA sarcomere
GO:0030018 IEA Z disc
GO:0030049 TAS muscle filament sliding
GO:0031143 TAS pseudopodium
GO:0042803 TAS protein homodimerization activity
GO:0042981 NAS regulation of apoptotic process
GO:0048041 IMP focal adhesion assembly
GO:0051015 IEA actin filament binding
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001431 actn3b actinin alpha 3b protein_coding Danio_rerio
ENSDARG00000013755 actn3a actinin alpha 3a protein_coding Danio_rerio
ENSMUSG00000006457 Actn3 actinin alpha 3 protein_coding Mus_musculus

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