C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000277893 SRD5A2 9606 - 2:31522480-31581067 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000622030 SRD5A2-001 31522480-31581067 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENST00000622030
Transcript ID Adrenal Bladder Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000622030 0.008±0.00 0.036±0.00 0.016±0.00 0.025±0.01 0.016±0.00 5.792±5.72 1.864±1.59 0.376±0.26 0.009±0.00 0.490±0.82 0.012±0.00 1.239±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000VC CIL_0000VC_0001 CGP 2:31334321-31581067
CIL_0003JI CIL_0003JI_0002 CGP 2:31522480-32011230

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003865 IEA 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0005737 IEA cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006629 IEA lipid metabolic process
GO:0006694 IEA steroid biosynthetic process
GO:0006702 TAS androgen biosynthetic process
GO:0006706 IEA steroid catabolic process
GO:0007267 TAS cell-cell signaling
GO:0008202 TAS:IEA steroid metabolic process
GO:0008209 IDA androgen metabolic process
GO:0008584 IMP male gonad development
GO:0009917 IDA sterol 5-alpha reductase activity
GO:0010033 IEA response to organic substance
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016627 IEA oxidoreductase activity, acting on the CH-CH group of donors
GO:0018879 IEA biphenyl metabolic process
GO:0018894 IEA dibenzo-p-dioxin metabolic process
GO:0018963 IEA phthalate metabolic process
GO:0021766 IEA hippocampus development
GO:0021854 IEA hypothalamus development
GO:0030154 IEA cell differentiation
GO:0030539 IEA male genitalia development
GO:0030540 IEA female genitalia development
GO:0031667 IEA response to nutrient levels
GO:0032354 IEA response to follicle-stimulating hormone
GO:0033218 IEA amide binding
GO:0033574 IEA response to testosterone
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043434 IEA response to peptide hormone
GO:0044281 TAS small molecule metabolic process
GO:0047751 IEA cholestenone 5-alpha-reductase activity
GO:0048545 IEA response to steroid hormone
GO:0055114 IEA oxidation-reduction process
GO:0060348 IEA bone development
GO:0070852 IEA cell body fiber

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039067 srd5a2b steroid-5-alpha-reductase, alpha polypeptide 2b protein_coding Danio_rerio
ENSDARG00000043587 srd5a2a steroid-5-alpha-reductase, alpha polypeptide 2a protein_coding Danio_rerio
ENSMUSG00000038541 Srd5a2 steroid 5 alpha-reductase 2 protein_coding Mus_musculus

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