C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin beta 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000290 Itgb2 10090 + 10:77530252-77565708 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000299 Itgb2-001 77530252-77565686 protein_coding
  ENSMUST00000130059 Itgb2-005 77530370-77548672 protein_coding
  ENSMUST00000131023 Itgb2-004 77530347-77547195 protein_coding
  ENSMUST00000153541 Itgb2-003 77530380-77565708 nonsense_mediated_decay
  ENSMUST00000156644 Itgb2-002 77530374-77565622 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000299ENSMUST00000130059ENSMUST00000153541ENSMUST00000156644
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000299 6.924±1.71 2.860±0.60 6.072±0.57 0.969±1.04 23.257±5.11 4.210±0.73 2.389±1.05 3.280±1.70 6.246±5.22 37.648±0.81 0.496±0.54 6.498±1.20 1.635±1.07 0.245±0.14
ENSMUST00000130059 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.214±0.00 N/A N/A N/A
ENSMUST00000153541 3.733±0.64 2.420±0.19 N/A N/A N/A 1.428±0.24 N/A 1.309±0.15 0.582±0.00 N/A 0.151±0.08 N/A 0.463±0.00 0.310±0.00
ENSMUST00000156644 N/A N/A N/A 0.050±0.00 N/A N/A N/A N/A 0.804±0.00 N/A 0.254±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001948 IEA glycoprotein binding
GO:0002523 IEA leukocyte migration involved in inflammatory response
GO:0004872 IEA receptor activity
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0007155 IMP cell adhesion
GO:0007159 IEA leukocyte cell-cell adhesion
GO:0007160 IEA cell-matrix adhesion
GO:0007229 IDA integrin-mediated signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007568 IEA aging
GO:0008305 IEA integrin complex
GO:0009986 IDA cell surface
GO:0016020 IDA membrane
GO:0016337 IGI single organismal cell-cell adhesion
GO:0019901 IEA protein kinase binding
GO:0030101 IEA natural killer cell activation
GO:0030369 IEA ICAM-3 receptor activity
GO:0030593 IMP neutrophil chemotaxis
GO:0031982 IEA vesicle
GO:0032403 IEA protein complex binding
GO:0034113 IEA heterotypic cell-cell adhesion
GO:0034687 IEA integrin alphaL-beta2 complex
GO:0035987 IEA endodermal cell differentiation
GO:0043113 IEA receptor clustering
GO:0043235 ISO receptor complex
GO:0043542 IEA endothelial cell migration
GO:0045121 IDA membrane raft
GO:0045123 IMP cellular extravasation
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045766 IEA positive regulation of angiogenesis
GO:0046982 IEA protein heterodimerization activity
GO:0050730 IEA regulation of peptidyl-tyrosine phosphorylation
GO:0050798 IMP activated T cell proliferation
GO:0050839 IEA cell adhesion molecule binding
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016939 itgb2 integrin, beta 2 protein_coding Danio_rerio
ENSG00000160255 ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) protein_coding Homo_sapiens

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