C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160255 ITGB2 9606 - 21:44885953-44931989 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302347 ITGB2-201 44885956-44921050 protein_coding
  ENST00000320216 ITGB2-010 44899067-44910630 protein_coding
  ENST00000355153 ITGB2-001 44885953-44928838 protein_coding
  ENST00000397846 ITGB2-008 44907987-44920896 protein_coding
  ENST00000397850 ITGB2-002 44885953-44928873 protein_coding
  ENST00000397852 ITGB2-005 44885953-44910826 protein_coding
  ENST00000397854 ITGB2-003 44885953-44920855 protein_coding
  ENST00000397857 ITGB2-004 44885953-44911460 protein_coding
  ENST00000475170 ITGB2-006 44885953-44894027 retained_intron
  ENST00000479202 ITGB2-011 44886333-44889131 retained_intron
  ENST00000479849 ITGB2-009 44907987-44910741 processed_transcript
  ENST00000498666 ITGB2-007 44885953-44920960 retained_intron
  ENST00000517563 ITGB2-015 44903503-44928718 protein_coding
  ENST00000517819 ITGB2-016 44907032-44921133 protein_coding
  ENST00000518033 ITGB2-019 44910321-44920927 retained_intron
  ENST00000520389 ITGB2-020 44903515-44920927 nonsense_mediated_decay
  ENST00000521987 ITGB2-018 44901551-44920932 processed_transcript
  ENST00000521995 ITGB2-014 44910284-44931989 protein_coding
  ENST00000522688 ITGB2-017 44903508-44920942 protein_coding
  ENST00000522931 ITGB2-022 44903384-44914283 protein_coding
  ENST00000523126 ITGB2-023 44909320-44910688 processed_transcript
  ENST00000523323 ITGB2-013 44885956-44920875 nonsense_mediated_decay
  ENST00000523663 ITGB2-024 44903365-44911177 protein_coding
  ENST00000524251 ITGB2-021 44906925-44920899 protein_coding
  ENST00000610622 ITGB2-202 44886358-44920869 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302347ENST00000320216ENST00000397852ENST00000397854ENST00000475170ENST00000479202ENST00000498666ENST00000517563ENST00000523323ENST00000610622
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302347 N/A N/A N/A 0.422±0.00 N/A 0.435±0.00 0.835±0.00 0.823±0.00 N/A N/A N/A 7.097±0.00 15.101±0.00 N/A
ENST00000320216 N/A N/A 0.879±0.00 1.312±0.00 8.860±0.00 2.767±0.00 0.799±0.00 N/A 4.482±0.00 10.740±0.00 N/A 6.874±0.00 N/A N/A
ENST00000397852 N/A N/A N/A 3.612±2.66 3.477±1.59 N/A N/A 5.906±1.95 1.993±0.13 10.775±4.16 N/A 7.657±7.12 37.905±14.95 N/A
ENST00000397854 16.479±0.00 29.169±0.00 N/A 4.996±0.00 6.028±0.00 2.871±0.00 4.510±0.00 5.345±0.00 2.560±0.00 13.154±0.00 2.221±0.00 6.940±0.00 7.348±0.00 5.213±0.00
ENST00000475170 N/A 15.220±0.00 0.736±0.00 N/A N/A 1.534±0.00 N/A N/A N/A N/A 0.845±0.00 2.459±0.00 N/A 1.627±0.22
ENST00000479202 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.696±0.00 N/A N/A
ENST00000498666 N/A N/A N/A N/A N/A 0.300±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000517563 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.896±0.00 N/A N/A
ENST00000523323 14.017±0.00 19.719±0.00 N/A N/A 10.719±0.00 2.582±0.00 5.345±0.00 N/A 4.101±0.00 55.169±0.00 0.628±0.00 3.817±0.33 N/A 3.616±0.00
ENST00000610622 N/A N/A N/A 0.475±0.00 6.308±0.33 0.810±0.00 N/A N/A N/A 4.781±0.00 N/A 4.513±0.00 17.724±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001948 IPI glycoprotein binding
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002523 IEA leukocyte migration involved in inflammatory response
GO:0004872 IEA receptor activity
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0006915 NAS apoptotic process
GO:0006954 NAS inflammatory response
GO:0007155 TAS cell adhesion
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007160 IEA:IMP cell-matrix adhesion
GO:0007229 IEA:NAS integrin-mediated signaling pathway
GO:0007267 NAS cell-cell signaling
GO:0007275 IEA multicellular organismal development
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008305 IEA:NAS integrin complex
GO:0008360 NAS regulation of cell shape
GO:0009986 IDA cell surface
GO:0016020 IDA:IEA membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0019901 IPI protein kinase binding
GO:0030101 IEA natural killer cell activation
GO:0030198 TAS extracellular matrix organization
GO:0030369 IMP ICAM-3 receptor activity
GO:0030593 IDA neutrophil chemotaxis
GO:0031982 IDA vesicle
GO:0032403 IEA protein complex binding
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034687 IDA integrin alphaL-beta2 complex
GO:0035987 IEP endodermal cell differentiation
GO:0043113 IMP receptor clustering
GO:0043235 IDA receptor complex
GO:0043542 IEA endothelial cell migration
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045123 IEA cellular extravasation
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045766 IEA positive regulation of angiogenesis
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0050730 IDA regulation of peptidyl-tyrosine phosphorylation
GO:0050776 TAS regulation of immune response
GO:0050798 IEA activated T cell proliferation
GO:0050839 IMP cell adhesion molecule binding
GO:0050900 TAS leukocyte migration
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016939 itgb2 integrin, beta 2 protein_coding Danio_rerio
ENSMUSG00000000290 Itgb2 integrin beta 2 protein_coding Mus_musculus

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