C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activin A receptor, type II-like 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000530 Acvrl1 10090 + 15:101128522-101145336 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000542 Acvrl1-001 101128522-101145336 protein_coding
  ENSMUST00000117984 Acvrl1-005 101128574-101143638 protein_coding
  ENSMUST00000119063 Acvrl1-003 101128922-101143640 protein_coding
  ENSMUST00000120028 Acvrl1-002 101128551-101143639 protein_coding
  ENSMUST00000120754 Acvrl1-006 101134133-101145336 protein_coding
  ENSMUST00000121718 Acvrl1-004 101128924-101143638 protein_coding
  ENSMUST00000124151 Acvrl1-009 101133415-101135462 protein_coding
  ENSMUST00000128525 Acvrl1-011 101137600-101142624 processed_transcript
  ENSMUST00000128868 Acvrl1-010 101135657-101137032 retained_intron
  ENSMUST00000130432 Acvrl1-008 101128551-101135311 protein_coding
  ENSMUST00000144229 Acvrl1-007 101128537-101134694 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000542ENSMUST00000117984ENSMUST00000119063ENSMUST00000120754ENSMUST00000128868
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000542 3.129±0.23 3.167±0.61 2.916±0.00 N/A 2.419±0.57 3.096±0.75 1.424±0.40 2.490±0.46 0.221±0.06 N/A 1.346±0.62 3.378±1.20 5.879±4.50 0.482±0.00
ENSMUST00000117984 9.090±1.76 5.731±1.11 10.524±1.32 1.362±0.51 6.718±2.40 7.318±1.79 4.831±2.20 4.750±0.43 0.607±0.18 81.791±29.38 1.214±0.30 8.582±2.91 17.561±20.42 0.566±0.12
ENSMUST00000119063 15.475±4.92 3.767±1.18 10.299±1.03 0.733±0.00 6.871±1.36 3.350±0.00 3.342±1.04 4.817±0.96 0.873±0.44 79.049±18.99 1.693±0.30 9.068±2.81 9.072±7.80 0.644±0.19
ENSMUST00000120754 8.160±0.92 2.071±0.00 14.031±0.45 1.942±0.38 4.557±1.42 7.244±0.94 2.715±0.55 1.967±0.67 0.489±0.30 118.862±6.00 1.718±0.00 5.476±1.95 11.792±8.51 0.467±0.09
ENSMUST00000128868 N/A N/A N/A 12.570±0.00 N/A N/A N/A N/A N/A N/A N/A 33.775±0.00 190.721±0.00 2.865±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006JX CIL_0006JX_0002 CGP 15:101115755-101145336
CIL_0006JY CIL_0006JY_0002 CGP 15:101128522-101213679

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0001701 IMP in utero embryonic development
GO:0001937 IDA negative regulation of endothelial cell proliferation
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0001946 IMP lymphangiogenesis
GO:0001974 IMP blood vessel remodeling
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005025 IEA transforming growth factor beta receptor activity, type I
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005887 IEA integral component of plasma membrane
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007162 IEA negative regulation of cell adhesion
GO:0007165 IEA signal transduction
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0008015 IEA blood circulation
GO:0008217 IEA regulation of blood pressure
GO:0008285 IEA negative regulation of cell proliferation
GO:0009986 IEA cell surface
GO:0010596 IEA negative regulation of endothelial cell migration
GO:0010862 IEA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016361 IEA activin receptor activity, type I
GO:0019901 IEA protein kinase binding
GO:0030308 IEA negative regulation of cell growth
GO:0030336 IEA negative regulation of cell migration
GO:0030425 IEA dendrite
GO:0030509 IMP BMP signaling pathway
GO:0030513 IDA positive regulation of BMP signaling pathway
GO:0032924 IEA activin receptor signaling pathway
GO:0035313 IEA wound healing, spreading of epidermal cells
GO:0042118 TAS endothelial cell activation
GO:0043025 IEA neuronal cell body
GO:0043537 IEA negative regulation of blood vessel endothelial cell migration
GO:0045602 IDA negative regulation of endothelial cell differentiation
GO:0045603 IDA positive regulation of endothelial cell differentiation
GO:0045766 IGI positive regulation of angiogenesis
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IEA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048185 IEA activin binding
GO:0048514 IMP blood vessel morphogenesis
GO:0050431 IEA transforming growth factor beta binding
GO:0051291 IEA protein heterooligomerization
GO:0051895 IEA negative regulation of focal adhesion assembly
GO:0060836 IMP lymphatic endothelial cell differentiation
GO:0060840 IMP artery development
GO:0060841 IMP venous blood vessel development
GO:0061154 IEA endothelial tube morphogenesis
GO:0061298 IMP retina vasculature development in camera-type eye
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0071773 IEA cellular response to BMP stimulus
GO:2000279 IEA negative regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018179 acvrl1 activin A receptor type II-like 1 protein_coding Danio_rerio
ENSG00000139567 ACVRL1 activin A receptor type II-like 1 protein_coding Homo_sapiens

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