C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: receptor (calcitonin) activity modifying protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000001240 Ramp2 10090 + 11:101246028-101259546 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000107282 Ramp2-003 101247093-101248064 protein_coding
  ENSMUST00000122006 Ramp2-002 101246429-101248250 protein_coding
  ENSMUST00000128260 Ramp2-008 101246391-101259546 nonsense_mediated_decay
  ENSMUST00000129680 Ramp2-001 101246028-101248250 protein_coding
  ENSMUST00000138229 Ramp2-007 101246933-101248250 retained_intron
  ENSMUST00000149006 Ramp2-004 101246312-101247684 retained_intron
  ENSMUST00000149585 Ramp2-005 101246432-101248250 nonsense_mediated_decay
  ENSMUST00000151830 Ramp2-006 101246567-101247636 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000128260ENSMUST00000129680ENSMUST00000138229ENSMUST00000149006ENSMUST00000149585
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000128260 N/A 16.076±5.26 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000129680 48.669±10.25 10.038±1.44 25.173±7.31 12.213±1.10 27.358±2.91 11.524±1.72 14.468±3.75 13.207±1.39 7.470±0.68 139.181±34.78 10.814±1.38 31.666±4.19 15.595±0.97 2.544±0.03
ENSMUST00000138229 85.301±27.43 N/A 15.615±0.00 13.654±0.53 55.692±16.48 N/A 33.309±3.41 27.746±1.38 15.853±3.66 186.104±8.88 N/A 32.489±4.19 21.357±7.84 N/A
ENSMUST00000149006 N/A 21.294±1.79 N/A N/A N/A N/A N/A N/A N/A N/A N/A 20.440±3.54 N/A N/A
ENSMUST00000149585 N/A 35.430±9.34 N/A N/A 30.792±2.49 N/A N/A N/A N/A 166.156±89.41 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004IN CIL_0004IN_0002 CGP 11:101191115-101259546
CIL_0004JZ CIL_0004JZ_0002 CGP 11:101246028-101259549

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 ISS angiogenesis
GO:0001570 IEA vasculogenesis
GO:0001666 IEA response to hypoxia
GO:0002040 IMP sprouting angiogenesis
GO:0005515 IEA protein binding
GO:0005737 ISS cytoplasm
GO:0005886 ISS plasma membrane
GO:0006171 ISS cAMP biosynthetic process
GO:0006816 ISS calcium ion transport
GO:0006886 IEA intracellular protein transport
GO:0007186 IPI G-protein coupled receptor signaling pathway
GO:0007507 IMP heart development
GO:0007565 IEA female pregnancy
GO:0008217 IMP regulation of blood pressure
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0008565 IEA protein transporter activity
GO:0009986 ISS cell surface
GO:0010628 IMP positive regulation of gene expression
GO:0015026 IDA coreceptor activity
GO:0015031 ISS protein transport
GO:0016021 IEA integral component of membrane
GO:0030819 ISS positive regulation of cAMP biosynthetic process
GO:0031623 ISS receptor internalization
GO:0032355 IEA response to estradiol
GO:0032570 IEA response to progesterone
GO:0032870 IEA cellular response to hormone stimulus
GO:0034333 IMP adherens junction assembly
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0043116 IMP negative regulation of vascular permeability
GO:0043235 ISS receptor complex
GO:0045766 IMP positive regulation of angiogenesis
GO:0070830 IMP tight junction assembly
GO:0070831 IMP basement membrane assembly
GO:0072659 ISS protein localization to plasma membrane
GO:0097084 IMP vascular smooth muscle cell development
GO:2000352 IMP negative regulation of endothelial cell apoptotic process
GO:2001214 IMP positive regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087020 receptor (G protein-coupled) activity modifying protein 2 protein_coding Danio_rerio
ENSG00000131477 RAMP2 receptor (G protein-coupled) activity modifying protein 2 protein_coding Homo_sapiens

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