C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Braf transforming gene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000002413 Braf 10090 - 6:39603237-39725463 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000002487 Braf-001 39603237-39725463 protein_coding
  ENSMUST00000101497 Braf-002 39614112-39725193 protein_coding
  ENSMUST00000167073 Braf-003 39639292-39644786 retained_intron
  ENSMUST00000167169 Braf-004 39640307-39643254 retained_intron
  ENSMUST00000169647 Braf-005 39651579-39665079 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryTestisENSMUST00000002487ENSMUST00000101497
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Testis
ENSMUST00000002487 4.047±0.00 7.056±2.73 3.576±0.00 2.695±0.00 3.151±0.80 3.508±0.25 3.271±0.69 4.316±0.00 1.150±0.16 4.221±0.53 2.505±1.65
ENSMUST00000101497 N/A N/A N/A N/A N/A N/A N/A N/A N/A 11.123±0.00 14.025±3.90

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00039Z CIL_00039Z_0002 CGP 6:39573873-39603382
CIL_00039Y CIL_00039Y_0002 CGP 6:39592574-39725463
CIL_000605 CIL_000605_0003 CGP 6:39603237-39810988

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0002318 IMP myeloid progenitor cell differentiation
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0005057 IEA receptor signaling protein activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005886 IDA plasma membrane
GO:0006468 IDA protein phosphorylation
GO:0008542 IMP visual learning
GO:0010628 IEA positive regulation of gene expression
GO:0010764 IMP negative regulation of fibroblast migration
GO:0016020 IEA membrane
GO:0030154 IGI cell differentiation
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0035019 IGI somatic stem cell maintenance
GO:0035556 IEA intracellular signal transduction
GO:0035690 IDA cellular response to drug
GO:0042127 IGI regulation of cell proliferation
GO:0042802 IEA identical protein binding
GO:0043005 IDA neuron projection
GO:0043066 IEA negative regulation of apoptotic process
GO:0043367 IMP CD4-positive, alpha-beta T cell differentiation
GO:0043368 IMP positive T cell selection
GO:0043434 IEA response to peptide hormone
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0044297 IDA cell body
GO:0046632 IMP alpha-beta T cell differentiation
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0051291 IEA protein heterooligomerization
GO:0051496 IGI positive regulation of stress fiber assembly
GO:0051591 IEA response to cAMP
GO:0060291 IMP long-term synaptic potentiation
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071277 IEA cellular response to calcium ion
GO:1900026 IMP positive regulation of substrate adhesion-dependent cell spreading
GO:2000301 IMP negative regulation of synaptic vesicle exocytosis
GO:2000352 IMP negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017661 braf v-raf murine sarcoma viral oncogene homolog B1 protein_coding Danio_rerio
ENSG00000157764 BRAF B-Raf proto-oncogene, serine/threonine kinase protein_coding Homo_sapiens

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