C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000006728 Cdk4 10090 + 10:127063534-127067920 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000006911 Cdk4-001 127063534-127067920 protein_coding
  ENSMUST00000120226 Cdk4-004 127063603-127067002 protein_coding
  ENSMUST00000123456 Cdk4-007 127064298-127065315 retained_intron
  ENSMUST00000125682 Cdk4-005 127063868-127066231 protein_coding
  ENSMUST00000133115 Cdk4-006 127063604-127066177 protein_coding
  ENSMUST00000135179 Cdk4-010 127063616-127065280 retained_intron
  ENSMUST00000140254 Cdk4-003 127063614-127067297 retained_intron
  ENSMUST00000142558 Cdk4-009 127063609-127067002 nonsense_mediated_decay
  ENSMUST00000145670 Cdk4-008 127066076-127067235 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000006911ENSMUST00000120226ENSMUST00000123456ENSMUST00000125682ENSMUST00000133115ENSMUST00000135179ENSMUST00000140254ENSMUST00000142558ENSMUST00000145670
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000006911 22.500±1.03 16.537±2.30 N/A 34.995±12.19 10.578±0.78 16.135±2.22 N/A 12.108±0.00 28.823±11.22 N/A N/A 25.141±1.53 27.961±4.86 3.549±0.37
ENSMUST00000120226 N/A 40.300±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000123456 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.692±0.00
ENSMUST00000125682 N/A N/A N/A 10.674±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.868±0.00
ENSMUST00000133115 69.246±20.67 N/A 42.593±0.00 129.965±139.97 33.915±4.86 28.684±6.75 26.713±4.73 44.300±10.39 79.479±22.85 41.533±13.62 12.055±0.00 148.348±48.54 88.493±29.62 9.516±1.01
ENSMUST00000135179 N/A N/A N/A N/A 62.931±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 14.088±0.00
ENSMUST00000140254 19.275±1.51 N/A 18.843±1.38 51.006±49.25 10.806±1.94 9.252±0.00 N/A N/A 19.548±2.81 10.918±0.45 4.338±0.89 32.562±2.65 23.778±0.00 4.827±0.48
ENSMUST00000142558 58.555±1.69 50.390±6.54 41.416±2.84 90.762±23.28 27.894±3.02 28.784±3.05 23.224±0.00 39.507±5.83 54.759±6.85 36.768±7.41 13.730±3.26 76.192±13.59 68.058±25.39 8.866±2.93
ENSMUST00000145670 N/A N/A N/A N/A N/A N/A N/A N/A 132.889±7.38 N/A N/A N/A 238.309±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IEA G1/S transition of mitotic cell cycle
GO:0000307 IPI cyclin-dependent protein kinase holoenzyme complex
GO:0000785 IEA chromatin
GO:0002088 IEA lens development in camera-type eye
GO:0004672 IDA protein kinase activity
GO:0004693 IDA cyclin-dependent protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005730 IEA nucleolus
GO:0005829 IEA cytosol
GO:0005923 IDA tight junction
GO:0006468 IDA protein phosphorylation
GO:0007165 IDA signal transduction
GO:0007623 IEA circadian rhythm
GO:0008284 IEA positive regulation of cell proliferation
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010288 IEA response to lead ion
GO:0010468 IEA regulation of gene expression
GO:0010971 ISS positive regulation of G2/M transition of mitotic cell cycle
GO:0016301 IDA kinase activity
GO:0030332 IEA cyclin binding
GO:0031100 IEA organ regeneration
GO:0031965 IEA nuclear membrane
GO:0032403 IEA protein complex binding
GO:0033574 IEA response to testosterone
GO:0042127 IMP regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0043065 IEA positive regulation of apoptotic process
GO:0045727 IEA positive regulation of translation
GO:0045793 IEA positive regulation of cell size
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051301 IEA cell division
GO:0051726 IDA regulation of cell cycle
GO:0055093 IEA response to hyperoxia
GO:0071157 ISS negative regulation of cell cycle arrest

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087937 cdk4 cyclin-dependent kinase 4 protein_coding Danio_rerio
ENSG00000135446 CDK4 cyclin-dependent kinase 4 protein_coding Homo_sapiens

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