C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135446 CDK4 9606 - 12:57747727-57756013 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000257904 CDK4-001 57747727-57752521 protein_coding
  ENST00000312990 CDK4-201 57748262-57752332 protein_coding
  ENST00000546489 CDK4-007 57748591-57752322 protein_coding
  ENST00000547281 CDK4-009 57749220-57752276 protein_coding
  ENST00000547853 CDK4-010 57751712-57752115 protein_coding
  ENST00000549606 CDK4-004 57748426-57752353 protein_coding
  ENST00000550419 CDK4-008 57749234-57752295 nonsense_mediated_decay
  ENST00000551706 CDK4-002 57750827-57752364 retained_intron
  ENST00000551800 CDK4-005 57750669-57752349 protein_coding
  ENST00000551888 CDK4-013 57749191-57752333 processed_transcript
  ENST00000552254 CDK4-011 57750679-57751877 protein_coding
  ENST00000552388 CDK4-006 57750934-57752322 protein_coding
  ENST00000552713 CDK4-014 57748411-57749795 retained_intron
  ENST00000552862 CDK4-012 57751215-57756013 protein_coding
  ENST00000553237 CDK4-003 57748520-57752326 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000257904ENST00000312990ENST00000546489ENST00000547281ENST00000551800ENST00000551888ENST00000552388ENST00000553237
Transcript ID Adipose Adrenal Bladder Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000257904 N/A 15.849±0.00 2.613±0.00 N/A N/A 20.164±0.00 2.425±0.00 12.339±5.87 N/A 19.327±15.79 26.203±0.23 N/A
ENST00000312990 22.977±0.00 50.377±0.00 N/A 44.356±0.00 20.053±0.00 30.645±0.00 17.608±0.00 32.133±0.00 16.880±0.00 79.418±24.96 41.484±15.62 30.131±16.09
ENST00000546489 N/A 48.746±0.00 N/A N/A N/A 9.385±0.00 N/A N/A N/A 63.826±54.57 57.621±0.00 20.022±0.00
ENST00000547281 N/A N/A N/A N/A N/A N/A N/A N/A N/A 109.855±0.00 47.138±0.00 18.808±0.00
ENST00000551800 N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.083±0.00 N/A N/A
ENST00000551888 N/A N/A N/A N/A N/A N/A N/A N/A N/A 19.963±0.00 N/A N/A
ENST00000552388 N/A N/A N/A N/A N/A N/A 9.653±0.00 N/A N/A N/A N/A N/A
ENST00000553237 N/A N/A N/A N/A N/A N/A N/A N/A 3.135±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002KQ CIL_0002KQ_0002 CGP 12:57723761-57750211

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000307 IDA cyclin-dependent protein kinase holoenzyme complex
GO:0000785 IDA chromatin
GO:0002088 IEA lens development in camera-type eye
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004693 IDA cyclin-dependent protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005730 IDA nucleolus
GO:0005829 IDA cytosol
GO:0005923 IEA tight junction
GO:0006468 IDA:IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007623 IEA circadian rhythm
GO:0008284 IMP positive regulation of cell proliferation
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010288 IEA response to lead ion
GO:0010468 IMP regulation of gene expression
GO:0010971 IDA positive regulation of G2/M transition of mitotic cell cycle
GO:0016301 IEA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030332 IPI cyclin binding
GO:0031100 IEA organ regeneration
GO:0031965 IDA nuclear membrane
GO:0032403 IEA protein complex binding
GO:0033574 IEA response to testosterone
GO:0042127 IEA regulation of cell proliferation
GO:0042493 IGI response to drug
GO:0043065 IEA positive regulation of apoptotic process
GO:0045727 IEA positive regulation of translation
GO:0045793 IEA positive regulation of cell size
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051301 IEA cell division
GO:0051726 IEA regulation of cell cycle
GO:0055093 IEA response to hyperoxia
GO:0071157 IDA negative regulation of cell cycle arrest

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087937 cdk4 cyclin-dependent kinase 4 protein_coding Danio_rerio
ENSMUSG00000006728 Cdk4 cyclin-dependent kinase 4 protein_coding Mus_musculus

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