C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: met proto-oncogene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000009376 Met 10090 + 6:17463800-17573980 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000080469 Met-201 17491241-17571823 protein_coding
  ENSMUST00000115442 Met-003 17464038-17572229 protein_coding
  ENSMUST00000115443 Met-001 17463800-17573980 protein_coding
  ENSMUST00000140070 Met-004 17463827-17491747 protein_coding
  ENSMUST00000145473 Met-002 17464107-17541412 retained_intron
  ENSMUST00000148903 Met-005 17546973-17553430 protein_coding
  ENSMUST00000152802 Met-006 17535001-17547210 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000080469ENSMUST00000115442ENSMUST00000115443ENSMUST00000140070
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000080469 N/A 0.466±0.17 N/A N/A 2.293±0.95 N/A N/A N/A N/A N/A N/A 1.132±0.33 N/A N/A
ENSMUST00000115442 2.553±0.70 N/A N/A 0.257±0.00 3.859±0.00 1.154±0.00 0.159±0.03 2.990±0.77 3.543±0.50 2.352±0.26 N/A N/A N/A 0.092±0.03
ENSMUST00000115443 4.190±0.89 0.525±0.21 6.914±0.04 0.514±0.24 4.080±1.15 4.762±0.77 0.244±0.12 12.279±1.22 3.988±1.55 7.523±0.27 1.667±0.63 2.218±0.67 1.116±0.48 0.127±0.05
ENSMUST00000140070 N/A 0.424±0.00 N/A N/A N/A 4.242±0.97 0.340±0.00 N/A N/A N/A N/A 1.786±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SP CIL_0007SP_0002 VISTA 6:16868699-17474875
CIL_00063L CIL_00063L_0003 CGP 6:17306335-17573980
CIL_00040Q CIL_00040Q_0002 CGP 6:17463800-17666972

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IPI activation of MAPK activity
GO:0001886 IEA endothelial cell morphogenesis
GO:0001889 IMP liver development
GO:0001890 IMP placenta development
GO:0004672 IDA protein kinase activity
GO:0005008 IDA hepatocyte growth factor-activated receptor activity
GO:0005524 IEA ATP binding
GO:0007420 IMP brain development
GO:0007517 IGI muscle organ development
GO:0007519 IMP skeletal muscle tissue development
GO:0009925 ISO basal plasma membrane
GO:0009986 IEA cell surface
GO:0010828 IMP positive regulation of glucose transport
GO:0014812 IMP muscle cell migration
GO:0014902 IMP myotube differentiation
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019903 IEA protein phosphatase binding
GO:0030534 IMP adult behavior
GO:0042593 IMP glucose homeostasis
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IDA protein autophosphorylation
GO:0048012 IDA hepatocyte growth factor receptor signaling pathway
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0050918 IEA positive chemotaxis
GO:0051450 IMP myoblast proliferation
GO:0060665 IMP regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526 IEA semaphorin-plexin signaling pathway
GO:1901299 IEA negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028 IEA positive regulation of endothelial cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070903 met met proto-oncogene (hepatocyte growth factor receptor) protein_coding Danio_rerio
ENSG00000105976 MET MET proto-oncogene, receptor tyrosine kinase protein_coding Homo_sapiens

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