C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MET proto-oncogene, receptor tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105976 MET 9606 + 7:116672390-116798386 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000318493 MET-001 116672405-116796342 protein_coding
  ENST00000397752 MET-002 116672392-116798386 protein_coding
  ENST00000422097 MET-004 116758517-116769909 protein_coding
  ENST00000436117 MET-201 116699085-116763080 protein_coding
  ENST00000454623 MET-007 116769666-116775072 protein_coding
  ENST00000456159 MET-005 116672390-116699599 protein_coding
  ENST00000495962 MET-003 116724146-116755414 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000318493ENST00000397752ENST00000436117
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000318493 N/A N/A 2.706±0.00 0.912±0.00 2.871±0.00 1.244±0.00 0.742±0.00 4.919±0.00 1.865±0.00 6.659±0.00 N/A 6.535±0.00 N/A N/A
ENST00000397752 4.872±0.00 0.551±0.00 2.893±0.00 1.980±1.02 2.761±1.43 1.463±0.00 1.316±0.00 3.086±0.67 1.849±0.00 1.567±0.37 N/A 8.432±6.53 6.922±0.79 1.329±0.00
ENST00000436117 N/A N/A 3.193±0.00 2.574±0.00 5.976±0.00 3.369±0.00 0.989±0.00 9.853±0.00 2.494±0.00 3.792±0.00 3.436±0.00 13.492±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00063L CIL_00063L_0002 CGP 7:116524785-116798386
CIL_00040Q CIL_00040Q_0001 CGP 7:116672390-116922049

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001886 IDA endothelial cell morphogenesis
GO:0001889 IEA liver development
GO:0001890 IEA placenta development
GO:0004672 IEA protein kinase activity
GO:0004713 NAS:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0004872 IEA receptor activity
GO:0005008 IEA hepatocyte growth factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 IEA extracellular region
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007166 NAS cell surface receptor signaling pathway
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007411 TAS axon guidance
GO:0007420 IEA brain development
GO:0007517 IEA muscle organ development
GO:0007519 IEA skeletal muscle tissue development
GO:0008283 TAS cell proliferation
GO:0009925 IDA basal plasma membrane
GO:0009986 IDA cell surface
GO:0010828 IEA positive regulation of glucose transport
GO:0014812 IEA muscle cell migration
GO:0014902 IEA myotube differentiation
GO:0016020 IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019903 IPI protein phosphatase binding
GO:0030534 IEA adult behavior
GO:0042593 IEA glucose homeostasis
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IEA protein autophosphorylation
GO:0048012 IEA hepatocyte growth factor receptor signaling pathway
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0050918 IDA positive chemotaxis
GO:0051450 IEA myoblast proliferation
GO:0060665 IEA regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526 IDA semaphorin-plexin signaling pathway
GO:1901299 IMP negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028 IMP positive regulation of endothelial cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070903 met met proto-oncogene (hepatocyte growth factor receptor) protein_coding Danio_rerio
ENSMUSG00000009376 Met met proto-oncogene protein_coding Mus_musculus

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