C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Wilms tumor 1 homolog
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000016458 Wt1 10090 + 2:105126529-105173616 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000111098 Wt1-008 105130883-105173612 protein_coding
  ENSMUST00000111099 Wt1-006 105130883-105173616 protein_coding
  ENSMUST00000133470 Wt1-002 105127001-105172265 protein_coding
  ENSMUST00000139585 Wt1-004 105127210-105172681 protein_coding
  ENSMUST00000143043 Wt1-001 105126529-105173612 protein_coding
  ENSMUST00000145107 Wt1-005 105130800-105133950 retained_intron
  ENSMUST00000146842 Wt1-003 105126996-105172342 protein_coding
  ENSMUST00000153944 Wt1-009 105162808-105170011 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000111098ENSMUST00000111099ENSMUST00000133470ENSMUST00000139585ENSMUST00000143043ENSMUST00000146842ENSMUST00000153944
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000111098 N/A N/A 0.486±0.16 0.024±0.01 N/A N/A 0.507±0.15 N/A 0.130±0.06 N/A N/A N/A 0.737±0.33 1.827±1.02
ENSMUST00000111099 N/A N/A N/A 0.036±0.00 N/A 0.149±0.00 N/A N/A 0.037±0.00 N/A N/A 5.300±0.00 0.210±0.06 1.670±0.00
ENSMUST00000133470 1.270±0.14 0.801±0.27 N/A 0.037±0.00 N/A 0.259±0.12 0.475±0.00 2.385±0.00 0.033±0.00 1.136±0.70 N/A 26.604±7.24 0.848±0.00 4.237±0.00
ENSMUST00000139585 23.675±20.02 0.599±0.00 0.706±0.36 0.072±0.00 N/A 0.538±0.16 1.542±0.20 4.711±0.82 0.277±0.21 1.391±0.39 N/A 19.587±4.42 1.260±0.68 10.023±1.63
ENSMUST00000143043 10.166±9.03 0.238±0.10 0.706±0.32 0.018±0.00 N/A 0.163±0.07 0.495±0.13 1.802±0.24 0.235±0.18 0.658±0.26 N/A 13.242±4.28 0.789±0.60 4.622±0.62
ENSMUST00000146842 N/A N/A N/A 0.043±0.00 0.026±0.00 0.294±0.00 N/A N/A 0.014±0.00 N/A 0.054±0.00 N/A N/A N/A
ENSMUST00000153944 N/A N/A N/A N/A N/A N/A N/A N/A 0.075±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SB CIL_0008SB_0002 VISTA 2:104593780-105194712
CIL_0008NI CIL_0008NI_0002 VISTA 2:105033715-105635145

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISO negative regulation of transcription from RNA polymerase II promoter
GO:0001570 IMP vasculogenesis
GO:0001656 IMP metanephros development
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001822 IEA kidney development
GO:0001823 IMP mesonephros development
GO:0003690 IDA double-stranded DNA binding
GO:0003723 IDA RNA binding
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005654 IEA nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006915 IMP apoptotic process
GO:0007281 IMP germ cell development
GO:0007283 IMP spermatogenesis
GO:0007338 IMP single fertilization
GO:0007507 IEA heart development
GO:0007530 IMP sex determination
GO:0008270 IEA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0008584 IMP male gonad development
GO:0009888 IMP tissue development
GO:0010468 IMP regulation of gene expression
GO:0016607 IEA nuclear speck
GO:0017148 IEA negative regulation of translation
GO:0030308 IEA negative regulation of cell growth
GO:0030317 IMP sperm motility
GO:0030325 IEA adrenal gland development
GO:0032835 IEA glomerulus development
GO:0032836 IEA glomerular basement membrane development
GO:0043010 IMP camera-type eye development
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0060009 IMP Sertoli cell development
GO:0061032 IEA visceral serous pericardium development
GO:0070742 IEA C2H2 zinc finger domain binding
GO:0071320 IBA cellular response to cAMP
GO:0071371 IBA cellular response to gonadotropin stimulus
GO:0072207 IEA metanephric epithelium development
GO:0072284 IEA metanephric S-shaped body morphogenesis
GO:0072520 IMP seminiferous tubule development
GO:1900212 IMP negative regulation of mesenchymal cell apoptotic process involved in metanephros development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007990 wt1b wilms tumor 1b protein_coding Danio_rerio
ENSDARG00000031420 wt1a wilms tumor 1a protein_coding Danio_rerio
ENSG00000184937 WT1 Wilms tumor 1 protein_coding Homo_sapiens

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