C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Wilms tumor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184937 WT1 9606 - 11:32387775-32435630 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332351 WT1-001 32387775-32435630 protein_coding
  ENST00000379077 WT1-005 32387775-32435387 nonsense_mediated_decay
  ENST00000379079 WT1-002 32387775-32430813 protein_coding
  ENST00000448076 WT1-009 32388679-32435535 protein_coding
  ENST00000452863 WT1-004 32387784-32435345 protein_coding
  ENST00000526685 WT1-007 32396257-32400615 protein_coding
  ENST00000527775 WT1-006 32396366-32429029 protein_coding
  ENST00000527882 WT1-008 32389042-32417597 protein_coding
  ENST00000530998 WT1-003 32387778-32430813 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000332351ENST00000379079ENST00000448076ENST00000452863ENST00000527775ENST00000530998
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000332351 N/A 0.327±0.00 N/A N/A N/A N/A N/A 0.025±0.00 N/A N/A 13.872±12.80 1.057±0.00 N/A
ENST00000379079 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.878±1.11
ENST00000448076 N/A N/A 0.032±0.00 N/A N/A N/A N/A N/A N/A N/A 0.031±0.00 1.987±0.40 6.874±0.00
ENST00000452863 N/A N/A 0.022±0.00 N/A N/A 0.654±0.36 6.239±0.00 0.150±0.00 0.135±0.00 0.015±0.00 17.746±8.95 1.669±0.26 5.292±0.00
ENST00000527775 N/A N/A N/A N/A 1.370±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000530998 0.031±0.00 N/A N/A 0.146±0.00 N/A N/A N/A N/A N/A N/A 3.366±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NI CIL_0008NI_0001 VISTA 11:31875944-32477188
CIL_0004RH CIL_0004RH_0002 CGP 11:32387775-32606262

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001077 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001570 ISS vasculogenesis
GO:0001656 IEA metanephros development
GO:0001657 ISS ureteric bud development
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0001822 IGI kidney development
GO:0001823 IEA mesonephros development
GO:0003156 ISS regulation of organ formation
GO:0003676 IEA nucleic acid binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0003723 IEA RNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 IDA:ISS cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS:IEA regulation of transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006915 IEA apoptotic process
GO:0007281 ISS germ cell development
GO:0007283 IEA spermatogenesis
GO:0007338 IEA single fertilization
GO:0007356 ISS thorax and anterior abdomen determination
GO:0007507 IGI heart development
GO:0007530 IDA sex determination
GO:0008270 IDA zinc ion binding
GO:0008285 IDA negative regulation of cell proliferation
GO:0008380 ISS RNA splicing
GO:0008406 ISS gonad development
GO:0008584 IEP male gonad development
GO:0009888 ISS tissue development
GO:0010468 IEA regulation of gene expression
GO:0016607 IDA nuclear speck
GO:0017148 IDA negative regulation of translation
GO:0030308 IDA negative regulation of cell growth
GO:0030317 IEA sperm motility
GO:0030325 IGI adrenal gland development
GO:0030539 ISS male genitalia development
GO:0030855 ISS epithelial cell differentiation
GO:0032835 IGI glomerulus development
GO:0032836 IMP glomerular basement membrane development
GO:0035802 ISS adrenal cortex formation
GO:0043010 ISS camera-type eye development
GO:0043065 IDA positive regulation of apoptotic process
GO:0043066 IGI negative regulation of apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IGI positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0060009 IEA Sertoli cell development
GO:0060231 ISS mesenchymal to epithelial transition
GO:0060421 ISS positive regulation of heart growth
GO:0060539 ISS diaphragm development
GO:0060923 ISS cardiac muscle cell fate commitment
GO:0061032 IGI visceral serous pericardium development
GO:0070742 IPI C2H2 zinc finger domain binding
GO:0071320 IEP cellular response to cAMP
GO:0071371 IDA cellular response to gonadotropin stimulus
GO:0072075 ISS metanephric mesenchyme development
GO:0072112 ISS glomerular visceral epithelial cell differentiation
GO:0072166 ISS posterior mesonephric tubule development
GO:0072207 IEP metanephric epithelium development
GO:0072284 IGI metanephric S-shaped body morphogenesis
GO:0072302 ISS negative regulation of metanephric glomerular mesangial cell proliferation
GO:0072520 IEA seminiferous tubule development
GO:1900212 IEA negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:2000020 ISS positive regulation of male gonad development
GO:2000195 ISS negative regulation of female gonad development
GO:2001076 ISS positive regulation of metanephric ureteric bud development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007990 wt1b wilms tumor 1b protein_coding Danio_rerio
ENSDARG00000031420 wt1a wilms tumor 1a protein_coding Danio_rerio
ENSMUSG00000016458 Wt1 Wilms tumor 1 homolog protein_coding Mus_musculus

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