C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mediator complex subunit 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018160 Med1 10090 - 11:98152154-98193293 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018304 Med1-002 98154248-98192955 protein_coding
  ENSMUST00000092735 Med1-004 98152154-98193260 protein_coding
  ENSMUST00000107545 Med1-001 98152155-98193293 protein_coding
  ENSMUST00000126483 Med1-006 98153011-98163957 processed_transcript
  ENSMUST00000129557 Med1-003 98169911-98193276 processed_transcript
  ENSMUST00000135479 Med1-005 98169363-98179996 processed_transcript
  ENSMUST00000147933 Med1-007 98157753-98161022 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000018304ENSMUST00000092735ENSMUST00000107545ENSMUST00000129557
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000018304 1.426±0.00 N/A N/A N/A 2.336±1.22 1.075±0.20 1.705±0.34 N/A N/A N/A N/A 3.176±1.32 0.807±0.00 2.718±0.83
ENSMUST00000092735 N/A N/A N/A N/A N/A N/A N/A N/A 2.487±0.69 N/A N/A N/A 3.382±1.43 5.021±3.36
ENSMUST00000107545 6.700±1.57 8.792±1.60 6.168±0.12 5.392±3.13 4.345±1.76 5.269±0.61 4.242±0.64 5.173±0.29 3.612±0.81 6.893±0.12 3.070±0.35 6.097±1.38 2.762±1.51 6.369±3.05
ENSMUST00000129557 N/A 15.405±3.63 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0002 VISTA 11:97857859-98458466
CIL_00080Z CIL_00080Z_0002 VISTA 11:98039002-98639485
CIL_00098W CIL_00098W_0002 VISTA 11:98077499-98680383
CIL_0007D6 CIL_0007D6_0002 CGP 11:98082556-98193293
CIL_0007WH CIL_0007WH_0002 VISTA 11:98091902-98695006
CIL_0007D3 CIL_0007D3_0002 CGP 11:98152154-98278504

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IEA chromatin
GO:0000902 ISS cell morphogenesis
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IMP sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 ISS core promoter binding
GO:0001104 ISS RNA polymerase II transcription cofactor activity
GO:0001525 IMP angiogenesis
GO:0001701 IMP in utero embryonic development
GO:0001889 IMP liver development
GO:0001892 IMP embryonic placenta development
GO:0002088 IMP lens development in camera-type eye
GO:0002154 ISS thyroid hormone mediated signaling pathway
GO:0003222 IMP ventricular trabecula myocardium morphogenesis
GO:0003406 IMP retinal pigment epithelium development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003712 IEA transcription cofactor activity
GO:0003713 TAS transcription coactivator activity
GO:0004872 ISS receptor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 ISS nucleolus
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0006356 ISS regulation of transcription from RNA polymerase I promoter
GO:0006366 IC transcription from RNA polymerase II promoter
GO:0006367 ISS transcription initiation from RNA polymerase II promoter
GO:0006590 IMP thyroid hormone generation
GO:0006702 ISS androgen biosynthetic process
GO:0007275 IMP multicellular organismal development
GO:0007420 IMP brain development
GO:0007507 IMP heart development
GO:0007595 IMP lactation
GO:0008134 IPI transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009887 IMP organ morphogenesis
GO:0010628 ISS positive regulation of gene expression
GO:0010839 ISS negative regulation of keratinocyte proliferation
GO:0016020 IEA membrane
GO:0016592 IDA mediator complex
GO:0016922 IEA ligand-dependent nuclear receptor binding
GO:0030216 ISS keratinocyte differentiation
GO:0030224 IMP monocyte differentiation
GO:0030331 IEA estrogen receptor binding
GO:0030374 ISS ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 IEA thyroid hormone receptor coactivator activity
GO:0030518 ISS intracellular steroid hormone receptor signaling pathway
GO:0030521 ISS androgen receptor signaling pathway
GO:0031100 IMP organ regeneration
GO:0031490 IEA chromatin DNA binding
GO:0032403 IDA protein complex binding
GO:0032993 IEA protein-DNA complex
GO:0033148 IMP positive regulation of intracellular estrogen receptor signaling pathway
GO:0033160 IMP positive regulation of protein import into nucleus, translocation
GO:0033598 IMP mammary gland epithelial cell proliferation
GO:0033601 IMP positive regulation of mammary gland epithelial cell proliferation
GO:0035050 IMP embryonic heart tube development
GO:0035116 IMP embryonic hindlimb morphogenesis
GO:0035162 IMP embryonic hemopoiesis
GO:0035257 IPI nuclear hormone receptor binding
GO:0035357 IMP peroxisome proliferator activated receptor signaling pathway
GO:0035729 IMP cellular response to hepatocyte growth factor stimulus
GO:0035855 IMP megakaryocyte development
GO:0036033 IEA mediator complex binding
GO:0042789 IMP mRNA transcription from RNA polymerase II promoter
GO:0042809 IEA vitamin D receptor binding
GO:0042974 IEA retinoic acid receptor binding
GO:0042975 IEA peroxisome proliferator activated receptor binding
GO:0043010 IMP camera-type eye development
GO:0043066 IMP negative regulation of apoptotic process
GO:0045444 IMP fat cell differentiation
GO:0045618 ISS positive regulation of keratinocyte differentiation
GO:0045665 IMP negative regulation of neuron differentiation
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046966 ISS thyroid hormone receptor binding
GO:0048821 IMP erythrocyte development
GO:0048822 IMP enucleate erythrocyte development
GO:0050693 IEA LBD domain binding
GO:0060335 IMP positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744 IMP mammary gland branching involved in thelarche
GO:0060745 IMP mammary gland branching involved in pregnancy
GO:0060750 IMP epithelial cell proliferation involved in mammary gland duct elongation
GO:0070318 IMP positive regulation of G0 to G1 transition
GO:0070371 IEA ERK1 and ERK2 cascade
GO:0070562 IMP regulation of vitamin D receptor signaling pathway
GO:0071364 ISS cellular response to epidermal growth factor stimulus
GO:0071383 IEA cellular response to steroid hormone stimulus
GO:0097067 IEA cellular response to thyroid hormone stimulus
GO:2000273 IEA positive regulation of receptor activity
GO:2000347 IMP positive regulation of hepatocyte proliferation
GO:2001141 ISS regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075340 med1 mediator complex subunit 1 protein_coding Danio_rerio
ENSG00000125686 MED1 mediator complex subunit 1 protein_coding Homo_sapiens

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