C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mediator complex subunit 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125686 MED1 9606 - 17:39404285-39451286 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300651 MED1-001 39406601-39451286 protein_coding
  ENST00000394287 MED1-002 39404285-39451268 protein_coding
  ENST00000577831 MED1-003 39407714-39451272 nonsense_mediated_decay
  ENST00000581334 MED1-005 39443550-39451272 nonsense_mediated_decay
  ENST00000584308 MED1-004 39427446-39431236 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000300651ENST00000394287ENST00000577831
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000300651 4.806±0.00 1.058±0.00 0.579±0.00 2.168±0.57 1.874±0.38 2.835±0.46 2.276±1.07 2.441±0.65 1.776±1.13 2.320±1.34 N/A 3.561±2.00 2.544±0.85 1.874±0.26
ENST00000394287 N/A N/A 1.156±0.00 1.145±0.00 2.248±0.00 N/A N/A N/A 2.529±0.00 1.355±0.00 N/A 3.238±0.00 N/A 1.450±0.00
ENST00000577831 N/A N/A N/A N/A 0.780±0.00 1.276±0.00 1.067±0.00 N/A N/A N/A 0.859±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0001 VISTA 17:39110111-39710718
CIL_0007D6 CIL_0007D6_0001 CGP 17:39252644-39451286
CIL_00080Z CIL_00080Z_0001 VISTA 17:39318232-39918735
CIL_00098W CIL_00098W_0001 VISTA 17:39359510-39962707
CIL_0007WH CIL_0007WH_0001 VISTA 17:39374871-39978277
CIL_0007D3 CIL_0007D3_0001 CGP 17:39404285-39564907

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IEA chromatin
GO:0000902 IMP cell morphogenesis
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 ISS sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 IDA core promoter binding
GO:0001104 IDA:IEA RNA polymerase II transcription cofactor activity
GO:0001525 ISS angiogenesis
GO:0001701 IEA in utero embryonic development
GO:0001889 IEA liver development
GO:0001892 IEA embryonic placenta development
GO:0002088 ISS lens development in camera-type eye
GO:0002154 IMP thyroid hormone mediated signaling pathway
GO:0003222 IEA ventricular trabecula myocardium morphogenesis
GO:0003406 IEA retinal pigment epithelium development
GO:0003677 IEA DNA binding
GO:0003682 IMP chromatin binding
GO:0003712 IDA transcription cofactor activity
GO:0003713 IDA transcription coactivator activity
GO:0004872 IDA receptor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IDA nucleolus
GO:0006356 IDA regulation of transcription from RNA polymerase I promoter
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006367 IDA transcription initiation from RNA polymerase II promoter
GO:0006590 IEA thyroid hormone generation
GO:0006702 IMP androgen biosynthetic process
GO:0007275 IEA multicellular organismal development
GO:0007420 IEA brain development
GO:0007507 IEA heart development
GO:0007595 IEA lactation
GO:0008134 IPI transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0009887 IEA organ morphogenesis
GO:0010467 TAS gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0010839 IMP negative regulation of keratinocyte proliferation
GO:0016020 IDA membrane
GO:0016592 IDA:IEA mediator complex
GO:0016922 IDA ligand-dependent nuclear receptor binding
GO:0030216 IMP keratinocyte differentiation
GO:0030224 IEA monocyte differentiation
GO:0030331 IPI estrogen receptor binding
GO:0030374 NAS ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 IMP thyroid hormone receptor coactivator activity
GO:0030518 IDA intracellular steroid hormone receptor signaling pathway
GO:0030521 IDA androgen receptor signaling pathway
GO:0031100 IEA organ regeneration
GO:0031490 IEA chromatin DNA binding
GO:0032403 IEA protein complex binding
GO:0032993 IEA protein-DNA complex
GO:0033148 IEA positive regulation of intracellular estrogen receptor signaling pathway
GO:0033160 IEA positive regulation of protein import into nucleus, translocation
GO:0033598 IEA mammary gland epithelial cell proliferation
GO:0033601 IEA positive regulation of mammary gland epithelial cell proliferation
GO:0035050 IEA embryonic heart tube development
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035162 IEA embryonic hemopoiesis
GO:0035257 IPI nuclear hormone receptor binding
GO:0035357 IEA peroxisome proliferator activated receptor signaling pathway
GO:0035729 IEA cellular response to hepatocyte growth factor stimulus
GO:0035855 ISS megakaryocyte development
GO:0036033 IDA mediator complex binding
GO:0042789 ISS mRNA transcription from RNA polymerase II promoter
GO:0042809 NAS vitamin D receptor binding
GO:0042974 IPI retinoic acid receptor binding
GO:0042975 IPI peroxisome proliferator activated receptor binding
GO:0043010 IEA camera-type eye development
GO:0043066 ISS negative regulation of apoptotic process
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045444 IDA fat cell differentiation
GO:0045618 IMP positive regulation of keratinocyte differentiation
GO:0045665 ISS negative regulation of neuron differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046966 IDA thyroid hormone receptor binding
GO:0048821 ISS erythrocyte development
GO:0048822 IEA enucleate erythrocyte development
GO:0050693 IPI LBD domain binding
GO:0051726 NAS regulation of cell cycle
GO:0060335 IEA positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744 IEA mammary gland branching involved in thelarche
GO:0060745 IEA mammary gland branching involved in pregnancy
GO:0060750 IEA epithelial cell proliferation involved in mammary gland duct elongation
GO:0070318 IEA positive regulation of G0 to G1 transition
GO:0070371 IDA ERK1 and ERK2 cascade
GO:0070562 IEA regulation of vitamin D receptor signaling pathway
GO:0071364 IDA cellular response to epidermal growth factor stimulus
GO:0071383 IDA cellular response to steroid hormone stimulus
GO:0097067 IDA cellular response to thyroid hormone stimulus
GO:2000273 IMP positive regulation of receptor activity
GO:2000347 IEA positive regulation of hepatocyte proliferation
GO:2001141 IMP regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075340 med1 mediator complex subunit 1 protein_coding Danio_rerio
ENSMUSG00000018160 Med1 mediator complex subunit 1 protein_coding Mus_musculus

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