C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine/threonine kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018209 Stk4 10090 + 2:164070322-164155524 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018353 Stk4-001 164074138-164155524 protein_coding
  ENSMUST00000088291 Stk4-003 164110201-164155524 protein_coding
  ENSMUST00000134078 Stk4-004 164070322-164086591 protein_coding
  ENSMUST00000137866 Stk4-002 164099720-164118369 protein_coding
  ENSMUST00000153319 Stk4-005 164081597-164096857 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000018353ENSMUST00000088291ENSMUST00000137866
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000018353 3.374±0.80 1.106±0.34 6.259±0.09 7.650±1.23 8.065±1.31 4.217±0.99 2.328±0.25 3.923±0.95 5.463±2.71 12.225±2.50 2.171±0.40 4.952±2.44 14.160±3.68 5.445±0.18
ENSMUST00000088291 3.633±1.01 6.684±0.56 1.524±0.40 1.573±0.00 9.028±3.29 5.133±1.28 0.975±0.33 2.544±0.79 1.582±0.34 7.003±0.46 0.440±0.09 5.533±1.70 N/A 2.793±1.06
ENSMUST00000137866 N/A N/A N/A 13.832±0.00 N/A N/A N/A N/A N/A N/A N/A 19.401±0.00 37.014±8.29 20.162±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZU CIL_0002ZU_0002 CGP 2:164025450-164071169
CIL_0003UT CIL_0003UT_0002 CGP 2:164053540-164155524
CIL_0003US CIL_0003US_0002 CGP 2:164070322-164171113

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0000902 ISO cell morphogenesis
GO:0001569 IGI patterning of blood vessels
GO:0001841 IGI neural tube formation
GO:0003157 IGI endocardium development
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006468 ISS protein phosphorylation
GO:0006915 ISS apoptotic process
GO:0007417 IGI central nervous system development
GO:0008134 IEA transcription factor binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0030216 IGI keratinocyte differentiation
GO:0035329 IGI hippo signaling
GO:0035556 IEA intracellular signal transduction
GO:0042802 IEA identical protein binding
GO:0042803 ISO protein homodimerization activity
GO:0043065 IGI positive regulation of apoptotic process
GO:0046621 IGI negative regulation of organ growth
GO:0046777 ISO protein autophosphorylation
GO:0046983 IEA protein dimerization activity
GO:0060215 IGI primitive hemopoiesis
GO:0060706 IGI cell differentiation involved in embryonic placenta development
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:0097284 IGI hepatocyte apoptotic process
GO:1902043 IGI positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000101109 STK4 serine/threonine kinase 4 protein_coding Homo_sapiens

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