C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interferon regulatory factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018899 Irf1 10090 + 11:53770014-53778374 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019043 Irf1-002 53770495-53777323 protein_coding
  ENSMUST00000108920 Irf1-001 53770014-53777323 protein_coding
  ENSMUST00000108922 Irf1-008 53770051-53778374 protein_coding
  ENSMUST00000123376 Irf1-005 53770487-53774194 protein_coding
  ENSMUST00000128336 Irf1-004 53770071-53776378 processed_transcript
  ENSMUST00000133291 Irf1-006 53770509-53773957 protein_coding
  ENSMUST00000138913 Irf1-007 53770477-53772938 protein_coding
  ENSMUST00000140866 Irf1-010 53770048-53775103 protein_coding
  ENSMUST00000142221 Irf1-009 53770105-53774085 nonsense_mediated_decay
  ENSMUST00000153054 Irf1-003 53773153-53774130 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019043ENSMUST00000108920ENSMUST00000128336ENSMUST00000138913ENSMUST00000140866ENSMUST00000142221ENSMUST00000153054
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019043 N/A N/A N/A 0.502±0.36 N/A N/A N/A N/A 2.255±1.10 N/A 0.561±0.06 3.780±0.00 1.349±0.00 0.408±0.00
ENSMUST00000108920 26.000±3.78 11.664±1.84 36.654±5.04 0.688±0.03 31.961±5.63 52.043±5.83 7.580±1.44 8.022±2.08 9.597±4.66 37.330±3.83 3.447±0.93 15.647±7.42 5.732±1.15 1.428±0.43
ENSMUST00000128336 N/A N/A N/A 1.790±0.00 38.058±19.91 N/A N/A N/A 7.445±0.68 N/A N/A 12.497±0.00 3.156±1.16 0.531±0.16
ENSMUST00000138913 N/A 16.530±0.10 N/A N/A N/A N/A N/A N/A 12.791±0.00 N/A N/A N/A N/A N/A
ENSMUST00000140866 19.313±1.91 26.377±3.39 N/A 0.486±0.00 84.160±5.23 107.208±23.39 N/A 7.800±1.33 6.941±2.44 55.263±27.14 N/A 13.041±1.67 2.314±0.00 0.964±0.00
ENSMUST00000142221 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 20.093±0.00 2.313±0.00 0.894±0.00
ENSMUST00000153054 N/A N/A N/A 1.216±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007RF CIL_0007RF_0002 VISTA 11:53756663-54359415
CIL_00093D CIL_00093D_0002 VISTA 11:53760072-54361368

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000975 IEA regulatory region DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0002819 TAS regulation of adaptive immune response
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IC nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006915 ISS apoptotic process
GO:0007050 ISS cell cycle arrest
GO:0010468 IMP regulation of gene expression
GO:0032481 IMP positive regulation of type I interferon production
GO:0032728 ISS positive regulation of interferon-beta production
GO:0032825 TAS positive regulation of natural killer cell differentiation
GO:0034124 IMP regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 IEA cellular response to interferon-beta
GO:0043374 IMP CD8-positive, alpha-beta T cell differentiation
GO:0043565 IDA sequence-specific DNA binding
GO:0045084 IDA positive regulation of interleukin-12 biosynthetic process
GO:0045088 TAS regulation of innate immune response
GO:0045590 IMP negative regulation of regulatory T cell differentiation
GO:0045627 TAS positive regulation of T-helper 1 cell differentiation
GO:0045629 TAS negative regulation of T-helper 2 cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 ISS defense response to virus
GO:0060333 IMP interferon-gamma-mediated signaling pathway
GO:0071260 IEA cellular response to mechanical stimulus
GO:2000564 IMP regulation of CD8-positive, alpha-beta T cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032768 irf1b interferon regulatory factor 1b protein_coding Danio_rerio
ENSG00000125347 IRF1 interferon regulatory factor 1 protein_coding Homo_sapiens

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