C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interferon regulatory factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125347 IRF1 9606 - 5:132481609-132490798 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000245414 IRF1-001 132481609-132490798 protein_coding
  ENST00000405885 IRF1-008 132483086-132490262 protein_coding
  ENST00000437654 IRF1-002 132485667-132490777 protein_coding
  ENST00000439555 IRF1-009 132486664-132490726 nonsense_mediated_decay
  ENST00000458069 IRF1-010 132486341-132490304 protein_coding
  ENST00000459982 IRF1-004 132486123-132490765 retained_intron
  ENST00000463784 IRF1-003 132486617-132490767 processed_transcript
  ENST00000472045 IRF1-006 132483085-132489032 retained_intron
  ENST00000476613 IRF1-007 132486962-132489645 protein_coding
  ENST00000493208 IRF1-005 132488671-132490754 retained_intron
  ENST00000613424 IRF1-201 132484051-132490655 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000245414ENST00000405885ENST00000437654ENST00000459982ENST00000472045ENST00000613424
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000245414 0.871±0.00 3.517±0.00 N/A 1.061±0.00 1.690±0.00 N/A 0.722±0.00 2.758±0.00 0.896±0.24 29.224±0.00 1.107±0.00 1.746±0.74 2.390±0.95 1.325±0.00
ENST00000405885 4.102±0.00 20.136±0.00 N/A 1.867±1.53 4.424±2.23 4.667±1.97 2.231±1.73 6.500±5.44 3.155±1.96 75.987±70.79 7.020±0.00 7.182±4.32 9.808±6.16 5.762±2.60
ENST00000437654 N/A N/A N/A N/A 6.718±0.00 3.665±0.00 1.251±0.00 3.294±0.00 8.509±0.00 5.366±0.00 3.640±0.00 N/A N/A N/A
ENST00000459982 N/A N/A N/A N/A N/A N/A N/A 3.822±0.00 N/A N/A N/A N/A N/A N/A
ENST00000472045 N/A 1.403±0.00 0.246±0.00 N/A 0.912±0.09 0.694±0.16 0.181±0.00 0.618±0.00 0.746±0.00 1.062±0.00 0.272±0.00 1.099±0.16 N/A 0.304±0.00
ENST00000613424 N/A N/A 1.383±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00093D CIL_00093D_0001 VISTA 5:131965137-132566411
CIL_0007RF CIL_0007RF_0001 VISTA 5:131967147-132570227

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000975 IEA regulatory region DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0002819 TAS regulation of adaptive immune response
GO:0003677 TAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006915 IDA apoptotic process
GO:0007050 IDA cell cycle arrest
GO:0007596 TAS blood coagulation
GO:0008285 TAS negative regulation of cell proliferation
GO:0010468 IEA regulation of gene expression
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0032481 ISS positive regulation of type I interferon production
GO:0032728 IMP positive regulation of interferon-beta production
GO:0034124 ISS regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 IDA cellular response to interferon-beta
GO:0043374 IEA CD8-positive, alpha-beta T cell differentiation
GO:0043565 IEA sequence-specific DNA binding
GO:0045084 IEA positive regulation of interleukin-12 biosynthetic process
GO:0045088 TAS regulation of innate immune response
GO:0045590 ISS negative regulation of regulatory T cell differentiation
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 IDA defense response to virus
GO:0051726 TAS regulation of cell cycle
GO:0060333 ISS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0071260 IEP cellular response to mechanical stimulus
GO:2000564 ISS regulation of CD8-positive, alpha-beta T cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032768 irf1b interferon regulatory factor 1b protein_coding Danio_rerio
ENSMUSG00000018899 Irf1 interferon regulatory factor 1 protein_coding Mus_musculus

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