C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interferon regulatory factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000108920 Irf1-001 ENSMUSG00000018899 10090 + 11:53770014-53777323 protein_coding

Mus musculus EnsemblGRCm38

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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000108920
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000108920 26.000±3.78 11.664±1.84 36.654±5.04 0.688±0.03 31.961±5.63 52.043±5.83 7.580±1.44 8.022±2.08 9.597±4.66 37.330±3.83 3.447±0.93 15.647±7.42 5.732±1.15 1.428±0.43

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007RF CIL_0007RF_0002 VISTA 11:53756663-54359415
CIL_00093D CIL_00093D_0002 VISTA 11:53760072-54361368

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0002819 TAS regulation of adaptive immune response
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IC nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006915 ISS apoptotic process
GO:0007050 ISS cell cycle arrest
GO:0010468 IMP regulation of gene expression
GO:0032481 IMP positive regulation of type I interferon production
GO:0032728 ISS positive regulation of interferon-beta production
GO:0032825 TAS positive regulation of natural killer cell differentiation
GO:0034124 IMP regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 IEA cellular response to interferon-beta
GO:0043374 IMP CD8-positive, alpha-beta T cell differentiation
GO:0043565 IDA sequence-specific DNA binding
GO:0045084 IDA positive regulation of interleukin-12 biosynthetic process
GO:0045088 TAS regulation of innate immune response
GO:0045590 IMP negative regulation of regulatory T cell differentiation
GO:0045627 TAS positive regulation of T-helper 1 cell differentiation
GO:0045629 TAS negative regulation of T-helper 2 cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 ISS defense response to virus
GO:0060333 IMP interferon-gamma-mediated signaling pathway
GO:0071260 IEA cellular response to mechanical stimulus
GO:2000564 IMP regulation of CD8-positive, alpha-beta T cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000245414 IRF1-001 protein_coding Homo_sapiens 0 1306
ENST00000405885 IRF1-008 protein_coding Homo_sapiens 0 1277
ENST00000437654 IRF1-002 protein_coding Homo_sapiens 0 680
ENST00000439555 IRF1-009 nonsense_mediated_decay Homo_sapiens 1e-39 167
ENST00000458069 IRF1-010 protein_coding Homo_sapiens 0 678
ENST00000459982 IRF1-004 retained_intron Homo_sapiens 0 516
ENST00000472045 IRF1-006 retained_intron Homo_sapiens 0 399
ENST00000476613 IRF1-007 protein_coding Homo_sapiens 0 510
ENST00000493208 IRF1-005 retained_intron Homo_sapiens 2e-39 167
ENST00000613424 IRF1-201 protein_coding Homo_sapiens 0 680

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