C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 2, group E, member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000019803 Nr2e1 10090 - 10:42561963-42583632 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019938 Nr2e1-001 42561963-42583632 protein_coding
  ENSMUST00000105498 Nr2e1-002 42563272-42568828 protein_coding
  ENSMUST00000126848 Nr2e1-003 42571484-42580345 protein_coding
  ENSMUST00000143891 Nr2e1-004 42572858-42580774 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonLiverOvaryPlacentaTestisENSMUST00000019938ENSMUST00000105498ENSMUST00000126848ENSMUST00000143891
Transcript ID Adrenal Brain Breast Colon Liver Ovary Placenta Testis
ENSMUST00000019938 0.020±0.01 8.470±7.47 0.014±0.00 0.018±0.00 0.009±0.00 0.167±0.10 0.002±0.00 0.045±0.02
ENSMUST00000105498 N/A N/A N/A N/A N/A 0.326±0.11 N/A 0.173±0.09
ENSMUST00000126848 N/A N/A N/A N/A 0.030±0.00 N/A N/A N/A
ENSMUST00000143891 N/A N/A N/A N/A N/A N/A N/A 0.263±0.18

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009BP CIL_0009BP_0002 VISTA 10:42334080-42935172
CIL_0008G4 CIL_0008G4_0002 VISTA 10:42335863-42936982
CIL_0007KA CIL_0007KA_0003 UCNEbase 10:42339928-43024116
CIL_0005K5 CIL_0005K5_0002 CGP 10:42502030-42583632
CIL_0005JL CIL_0005JL_0002 CGP 10:42561963-42702459

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001662 IMP behavioral fear response
GO:0002118 IMP aggressive behavior
GO:0003677 IDA DNA binding
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0007420 IMP brain development
GO:0007601 IMP visual perception
GO:0008270 IEA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008347 IMP glial cell migration
GO:0019899 IPI enzyme binding
GO:0021542 IMP dentate gyrus development
GO:0021764 IMP amygdala development
GO:0021772 IMP olfactory bulb development
GO:0021819 IMP layer formation in cerebral cortex
GO:0021872 IMP forebrain generation of neurons
GO:0021895 IMP cerebral cortex neuron differentiation
GO:0021960 IMP anterior commissure morphogenesis
GO:0021987 IMP cerebral cortex development
GO:0030198 IMP extracellular matrix organization
GO:0030522 IEA intracellular receptor signaling pathway
GO:0035019 IMP somatic stem cell maintenance
GO:0035176 IMP social behavior
GO:0042826 IPI histone deacetylase binding
GO:0043010 IMP camera-type eye development
GO:0043066 IMP negative regulation of apoptotic process
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0045165 IGI cell fate commitment
GO:0045665 IMP negative regulation of neuron differentiation
GO:0045766 IMP positive regulation of angiogenesis
GO:0045787 IMP positive regulation of cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048712 IMP negative regulation of astrocyte differentiation
GO:0048814 IMP regulation of dendrite morphogenesis
GO:0051128 IMP regulation of cellular component organization
GO:0060041 IMP retina development in camera-type eye
GO:0060164 IMP regulation of timing of neuron differentiation
GO:0060291 IMP long-term synaptic potentiation
GO:0090049 IMP regulation of cell migration involved in sprouting angiogenesis
GO:2000178 IMP negative regulation of neural precursor cell proliferation
GO:2000179 IMP positive regulation of neural precursor cell proliferation
GO:2000648 IMP positive regulation of stem cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017107 nr2e1 nuclear receptor subfamily 2, group E, member 1 protein_coding Danio_rerio
ENSG00000112333 NR2E1 nuclear receptor subfamily 2, group E, member 1 protein_coding Homo_sapiens

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