C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tumor necrosis factor, alpha-induced protein 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000019850 Tnfaip3 10090 - 10:19000910-19015657 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019997 Tnfaip3-001 19000910-19015410 protein_coding
  ENSMUST00000105527 Tnfaip3-002 19000913-19011963 protein_coding
  ENSMUST00000122863 Tnfaip3-004 19008266-19015657 protein_coding
  ENSMUST00000146388 Tnfaip3-005 19011516-19014582 protein_coding
  ENSMUST00000154590 Tnfaip3-003 19000929-19015376 retained_intron
  ENSMUST00000154749 Tnfaip3-006 19007267-19008845 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019997ENSMUST00000105527ENSMUST00000154590
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019997 1.709±0.28 1.061±0.15 1.424±0.01 0.863±0.15 4.913±2.09 6.968±1.70 0.603±0.12 0.995±0.23 0.468±0.35 3.858±0.25 0.979±0.30 0.928±0.35 0.981±0.34 0.481±0.23
ENSMUST00000105527 N/A N/A 0.289±0.00 N/A N/A N/A N/A N/A 0.079±0.03 N/A 0.349±0.00 0.257±0.00 0.501±0.06 0.407±0.00
ENSMUST00000154590 0.180±0.05 0.170±0.06 N/A N/A N/A 0.859±0.13 0.068±0.00 0.127±0.00 0.089±0.01 0.383±0.00 N/A 0.173±0.06 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008JD CIL_0008JD_0002 VISTA 10:18777703-19380447
CIL_000081 CIL_000081_0002 CGP 10:18845071-19015657

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001922 IMP B-1 B cell homeostasis
GO:0002020 IEA protease binding
GO:0002237 IDA response to molecule of bacterial origin
GO:0002315 NAS marginal zone B cell differentiation
GO:0002632 NAS negative regulation of granuloma formation
GO:0002634 IMP regulation of germinal center formation
GO:0002637 IC regulation of immunoglobulin production
GO:0002677 IMP negative regulation of chronic inflammatory response
GO:0003677 IEA DNA binding
GO:0004221 ISS ubiquitin thiolesterase activity
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0004843 ISS ubiquitin-specific protease activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005764 IEA lysosome
GO:0005813 IEA centrosome
GO:0006508 IEA proteolysis
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0008270 IEA zinc ion binding
GO:0009611 NAS response to wounding
GO:0010507 NAS negative regulation of autophagy
GO:0016579 IDA protein deubiquitination
GO:0016874 IEA ligase activity
GO:0019900 IDA kinase binding
GO:0031397 IEA negative regulation of protein ubiquitination
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032495 IMP response to muramyl dipeptide
GO:0032691 IMP negative regulation of interleukin-1 beta production
GO:0032703 IEA negative regulation of interleukin-2 production
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0034115 NAS negative regulation of heterotypic cell-cell adhesion
GO:0034140 IEA negative regulation of toll-like receptor 3 signaling pathway
GO:0034148 IDA negative regulation of toll-like receptor 5 signaling pathway
GO:0035871 ISS protein K11-linked deubiquitination
GO:0043124 ISS negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 IEA ubiquitin binding
GO:0043621 IEA protein self-association
GO:0045088 IC regulation of innate immune response
GO:0045732 ISS positive regulation of protein catabolic process
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045824 IMP negative regulation of innate immune response
GO:0048662 ISS negative regulation of smooth muscle cell proliferation
GO:0050728 IMP negative regulation of inflammatory response
GO:0050869 IDA negative regulation of B cell activation
GO:0060548 IMP negative regulation of cell death
GO:0070062 IEA extracellular vesicular exosome
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0070429 IMP negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433 IDA negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070536 IDA:ISS protein K63-linked deubiquitination
GO:0070936 ISS protein K48-linked ubiquitination
GO:0071108 ISS protein K48-linked deubiquitination
GO:0071222 ISS cellular response to lipopolysaccharide
GO:0072573 IEA tolerance induction to lipopolysaccharide
GO:0072666 IDA establishment of protein localization to vacuole
GO:1902042 NAS negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903364 IDA positive regulation of cellular protein catabolic process
GO:2000347 IDA positive regulation of hepatocyte proliferation
GO:2000349 ISS negative regulation of CD40 signaling pathway
GO:2000352 IEA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027777 tnfaip3 tumor necrosis factor, alpha-induced protein 3 protein_coding Danio_rerio
ENSG00000118503 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 protein_coding Homo_sapiens

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