C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tumor necrosis factor, alpha-induced protein 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000118503 TNFAIP3 9606 + 6:137867188-137883312 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000237289 TNFAIP3-001 137867444-137883312 protein_coding
  ENST00000420009 TNFAIP3-003 137867322-137875035 protein_coding
  ENST00000421450 TNFAIP3-002 137867214-137871304 protein_coding
  ENST00000433680 TNFAIP3-004 137867582-137871522 protein_coding
  ENST00000485192 TNFAIP3-005 137875838-137878525 processed_transcript
  ENST00000612899 TNFAIP3-201 137867188-137883311 protein_coding
  ENST00000614035 TNFAIP3-202 137871228-137878860 protein_coding
  ENST00000614451 TNFAIP3-203 137867236-137881319 protein_coding
  ENST00000615468 TNFAIP3-204 137871211-137882748 protein_coding
  ENST00000619035 TNFAIP3-205 137871211-137882748 protein_coding
  ENST00000620204 TNFAIP3-206 137871211-137882748 protein_coding
  ENST00000621150 TNFAIP3-207 137871228-137879043 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000237289ENST00000420009ENST00000433680ENST00000485192ENST00000612899ENST00000614035ENST00000614451ENST00000615468
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000237289 7.164±0.00 6.633±0.00 N/A N/A 0.901±0.00 1.802±0.00 0.496±0.00 0.977±0.30 0.689±0.00 5.730±0.00 1.724±0.00 21.225±10.57 7.667±3.46 3.939±0.15
ENST00000420009 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.926±0.00
ENST00000433680 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 23.258±0.00 N/A
ENST00000485192 N/A N/A N/A 1.442±0.00 N/A N/A N/A N/A N/A N/A 0.987±0.00 N/A N/A N/A
ENST00000612899 4.432±0.00 N/A N/A 0.308±0.00 1.940±0.00 1.912±0.00 0.397±0.00 1.101±0.00 1.948±0.00 7.406±5.60 N/A 4.720±0.00 2.371±0.23 2.299±0.86
ENST00000614035 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.202±0.00 N/A N/A N/A N/A
ENST00000614451 N/A N/A N/A N/A N/A N/A 0.326±0.00 N/A 2.100±0.00 N/A N/A N/A N/A N/A
ENST00000615468 6.014±0.00 4.329±0.00 0.424±0.00 0.261±0.16 1.904±0.00 2.481±0.55 0.910±0.00 0.561±0.00 1.436±0.77 13.250±11.09 1.842±0.00 N/A 2.836±0.85 1.284±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008JD CIL_0008JD_0001 VISTA 6:137510749-138112161

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001922 ISS B-1 B cell homeostasis
GO:0002020 IPI protease binding
GO:0002237 IDA response to molecule of bacterial origin
GO:0002634 ISS regulation of germinal center formation
GO:0002677 IEA negative regulation of chronic inflammatory response
GO:0003677 IEA DNA binding
GO:0004221 IMP ubiquitin thiolesterase activity
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0004843 IDA ubiquitin-specific protease activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005764 IEA lysosome
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0006508 IEA proteolysis
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0008270 IEA zinc ion binding
GO:0016579 TAS protein deubiquitination
GO:0016874 IEA ligase activity
GO:0019900 IEA kinase binding
GO:0031397 IDA negative regulation of protein ubiquitination
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032480 TAS negative regulation of type I interferon production
GO:0032495 IEA response to muramyl dipeptide
GO:0032691 IEA negative regulation of interleukin-1 beta production
GO:0032703 IMP negative regulation of interleukin-2 production
GO:0032715 ISS negative regulation of interleukin-6 production
GO:0032720 ISS negative regulation of tumor necrosis factor production
GO:0034136 NAS negative regulation of toll-like receptor 2 signaling pathway
GO:0034140 IDA negative regulation of toll-like receptor 3 signaling pathway
GO:0034144 NAS negative regulation of toll-like receptor 4 signaling pathway
GO:0034148 IEA negative regulation of toll-like receptor 5 signaling pathway
GO:0035871 IDA protein K11-linked deubiquitination
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 IPI ubiquitin binding
GO:0043621 IDA protein self-association
GO:0045087 TAS innate immune response
GO:0045732 IDA positive regulation of protein catabolic process
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045779 NAS negative regulation of bone resorption
GO:0045824 ISS negative regulation of innate immune response
GO:0048662 IDA negative regulation of smooth muscle cell proliferation
GO:0050691 NAS regulation of defense response to virus by host
GO:0050728 ISS negative regulation of inflammatory response
GO:0050869 ISS negative regulation of B cell activation
GO:0051259 NAS protein oligomerization
GO:0060548 IEA negative regulation of cell death
GO:0061043 NAS regulation of vascular wound healing
GO:0070062 IDA extracellular vesicular exosome
GO:0070301 ISS cellular response to hydrogen peroxide
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070429 IEA negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433 IEA negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070536 IDA protein K63-linked deubiquitination
GO:0070936 IDA protein K48-linked ubiquitination
GO:0071108 IDA protein K48-linked deubiquitination
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0072573 IMP tolerance induction to lipopolysaccharide
GO:0072666 IEA establishment of protein localization to vacuole
GO:0090291 NAS negative regulation of osteoclast proliferation
GO:1902042 IDA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903364 IEA positive regulation of cellular protein catabolic process
GO:2000347 IEA positive regulation of hepatocyte proliferation
GO:2000349 IMP negative regulation of CD40 signaling pathway
GO:2000352 IDA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027777 tnfaip3 tumor necrosis factor, alpha-induced protein 3 protein_coding Danio_rerio
ENSMUSG00000019850 Tnfaip3 tumor necrosis factor, alpha-induced protein 3 protein_coding Mus_musculus

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