C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: achaete-scute complex homolog 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020052 Ascl1 10090 - 10:87490819-87493660 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020243 Ascl1-001 87490819-87493660 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020243
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020243 0.463±0.11 0.820±0.17 0.084±0.03 12.030±8.19 1.114±0.29 0.270±0.08 0.020±0.01 0.063±0.02 0.035±0.03 0.566±0.14 0.023±0.00 0.097±0.06 0.075±0.04 0.016±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WM CIL_0007WM_0002 VISTA 10:86992836-87593886
CIL_00083Z CIL_00083Z_0002 VISTA 10:87024267-87626929
CIL_0008OX CIL_0008OX_0002 VISTA 10:87088706-87689893
CIL_0008TA CIL_0008TA_0002 VISTA 10:87145159-87749773
CIL_0009AL CIL_0009AL_0002 VISTA 10:87146548-87749489
CIL_0008NV CIL_0008NV_0002 VISTA 10:87146634-87748659
CIL_0008WZ CIL_0008WZ_0002 VISTA 10:87173282-87774591
CIL_0008O5 CIL_0008O5_0002 VISTA 10:87200258-87801668

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000989 IDA transcription factor binding transcription factor activity
GO:0001764 IGI neuron migration
GO:0003358 IMP noradrenergic neuron development
GO:0003359 IEA noradrenergic neuron fate commitment
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0007219 IGI Notch signaling pathway
GO:0007346 IMP regulation of mitotic cell cycle
GO:0007389 IMP pattern specification process
GO:0007399 IEA nervous system development
GO:0007400 IMP neuroblast fate determination
GO:0007405 IGI neuroblast proliferation
GO:0008593 IMP regulation of Notch signaling pathway
GO:0010001 IGI glial cell differentiation
GO:0010226 IEA response to lithium ion
GO:0010468 IMP regulation of gene expression
GO:0014003 IMP oligodendrocyte development
GO:0021527 IMP spinal cord association neuron differentiation
GO:0021529 IGI spinal cord oligodendrocyte cell differentiation
GO:0021530 IMP spinal cord oligodendrocyte cell fate specification
GO:0021750 IMP vestibular nucleus development
GO:0021779 IMP oligodendrocyte cell fate commitment
GO:0021879 IEA forebrain neuron differentiation
GO:0021892 IEA cerebral cortex GABAergic interneuron differentiation
GO:0021902 IMP commitment of neuronal cell to specific neuron type in forebrain
GO:0021954 IGI central nervous system neuron development
GO:0021987 IMP cerebral cortex development
GO:0022008 IDA neurogenesis
GO:0030154 IMP cell differentiation
GO:0030182 IGI neuron differentiation
GO:0030856 IMP regulation of epithelial cell differentiation
GO:0032526 IEA response to retinoic acid
GO:0042127 IDA regulation of cell proliferation
GO:0042803 IEA protein homodimerization activity
GO:0043025 IDA neuronal cell body
GO:0043066 IEA negative regulation of apoptotic process
GO:0043425 IEA bHLH transcription factor binding
GO:0043525 IMP positive regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045747 IMP positive regulation of Notch signaling pathway
GO:0045787 IDA positive regulation of cell cycle
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048469 IMP cell maturation
GO:0048484 TAS enteric nervous system development
GO:0048485 TAS sympathetic nervous system development
GO:0048486 TAS parasympathetic nervous system development
GO:0048663 IMP neuron fate commitment
GO:0048665 IMP neuron fate specification
GO:0048666 IMP neuron development
GO:0048699 IMP generation of neurons
GO:0048709 IMP oligodendrocyte differentiation
GO:0050767 IMP regulation of neurogenesis
GO:0050769 IMP positive regulation of neurogenesis
GO:0050883 IMP musculoskeletal movement, spinal reflex action
GO:0051593 IEA response to folic acid
GO:0060163 IMP subpallium neuron fate commitment
GO:0060165 IMP regulation of timing of subpallium neuron differentiation
GO:0060166 IMP olfactory pit development
GO:0060579 IMP ventral spinal cord interneuron fate commitment
GO:0061100 IMP lung neuroendocrine cell differentiation
GO:0061102 IMP stomach neuroendocrine cell differentiation
GO:0061103 IMP carotid body glomus cell differentiation
GO:0061104 IMP adrenal chromaffin cell differentiation
GO:0061549 IMP sympathetic ganglion development
GO:0070849 IEA response to epidermal growth factor
GO:0070888 IEA E-box binding
GO:0071259 IEA cellular response to magnetism
GO:2000179 IMP positive regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038386 ascl1a achaete-scute complex-like 1a (Drosophila) protein_coding Danio_rerio
ENSG00000139352 ASCL1 achaete-scute family bHLH transcription factor 1 protein_coding Homo_sapiens

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