C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transformed mouse 3T3 cell double minute 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020184 Mdm2 10090 - 10:117688888-117710758 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020408 Mdm2-001 117688888-117710758 protein_coding
  ENSMUST00000105263 Mdm2-002 117688888-117710758 protein_coding
  ENSMUST00000126022 Mdm2-007 117696041-117710711 processed_transcript
  ENSMUST00000131627 Mdm2-009 117690243-117691520 retained_intron
  ENSMUST00000132277 Mdm2-004 117690109-117710685 retained_intron
  ENSMUST00000137102 Mdm2-006 117694934-117710078 processed_transcript
  ENSMUST00000147823 Mdm2-005 117702259-117710292 processed_transcript
  ENSMUST00000151725 Mdm2-008 117709718-117710714 retained_intron
  ENSMUST00000155285 Mdm2-003 117688895-117710022 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020408ENSMUST00000126022ENSMUST00000131627ENSMUST00000132277ENSMUST00000151725ENSMUST00000155285
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020408 8.254±1.50 12.058±2.21 18.195±3.37 10.680±6.13 10.309±4.68 12.626±2.25 8.397±2.70 9.547±1.58 7.248±2.75 14.302±2.02 7.460±1.42 13.877±3.68 18.225±6.13 34.176±13.53
ENSMUST00000126022 N/A 65.528±10.39 N/A N/A 12.605±0.00 17.395±5.65 N/A N/A N/A N/A N/A 19.809±4.83 N/A N/A
ENSMUST00000131627 N/A N/A N/A 8.737±0.00 N/A N/A N/A N/A N/A N/A N/A 19.890±0.00 N/A 50.150±0.00
ENSMUST00000132277 N/A N/A 4.157±0.00 3.391±0.00 1.869±0.00 N/A N/A N/A 1.188±0.16 N/A N/A 3.057±0.00 N/A N/A
ENSMUST00000151725 N/A N/A N/A N/A N/A 7.035±0.00 N/A N/A 4.159±0.00 N/A N/A 8.832±0.10 N/A N/A
ENSMUST00000155285 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.715±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0002039 IPI p53 binding
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0006461 IEA protein complex assembly
GO:0006977 IEA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089 IDA traversing start control point of mitotic cell cycle
GO:0009636 IEA response to toxic substance
GO:0009743 IEA response to carbohydrate
GO:0010039 IEA response to iron ion
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010955 IEA negative regulation of protein processing
GO:0016567 ISS protein ubiquitination
GO:0016604 IEA nuclear body
GO:0016874 IEA ligase activity
GO:0018205 IEA peptidyl-lysine modification
GO:0019899 IEA enzyme binding
GO:0030163 IDA protein catabolic process
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031648 IEA protein destabilization
GO:0032026 IEA response to magnesium ion
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 IEA protein localization to nucleus
GO:0042176 IEA regulation of protein catabolic process
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0042787 IEA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IEA identical protein binding
GO:0042975 IEA peroxisome proliferator activated receptor binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043234 IEA protein complex
GO:0043278 IEA response to morphine
GO:0043518 IEA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045184 IEA establishment of protein localization
GO:0045202 IEA synapse
GO:0045472 IEA response to ether
GO:0045787 IGI positive regulation of cell cycle
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0046677 IEA response to antibiotic
GO:0046827 IEA positive regulation of protein export from nucleus
GO:0048545 IEA response to steroid hormone
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071157 IEA negative regulation of cell cycle arrest
GO:0071229 IEA cellular response to acid
GO:0071236 IEA cellular response to antibiotic
GO:0071301 IEA cellular response to vitamin B1
GO:0071310 IEA cellular response to organic substance
GO:0071312 IEA cellular response to alkaloid
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071391 IEA cellular response to estrogen stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071456 IEA cellular response to hypoxia
GO:0071494 IEA cellular response to UV-C
GO:0097110 IPI scaffold protein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033443 mdm2 transformed 3T3 cell double minute 2 homolog (mouse) protein_coding Danio_rerio
ENSG00000135679 MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase protein_coding Homo_sapiens

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