C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MDM2 proto-oncogene, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135679 MDM2 9606 + 12:68808172-68850686 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000258148 MDM2-003 68808464-68839867 protein_coding
  ENST00000258149 MDM2-001 68808176-68850686 protein_coding
  ENST00000299252 MDM2-006 68809212-68839849 protein_coding
  ENST00000311420 MDM2-010 68808273-68839867 nonsense_mediated_decay
  ENST00000348801 MDM2-009 68809227-68839849 protein_coding
  ENST00000350057 MDM2-033 68809212-68839849 protein_coding
  ENST00000356290 MDM2-201 68809017-68845544 protein_coding
  ENST00000360430 MDM2-008 68809212-68839849 protein_coding
  ENST00000393410 MDM2-004 68809212-68839849 protein_coding
  ENST00000393412 MDM2-202 68808191-68840216 protein_coding
  ENST00000393413 MDM2-032 68809212-68839849 protein_coding
  ENST00000393415 MDM2-022 68809017-68839282 protein_coding
  ENST00000393416 MDM2-013 68809024-68828859 protein_coding
  ENST00000393417 MDM2-002 68808383-68839856 nonsense_mediated_decay
  ENST00000400501 MDM2-044 68843689-68844195 processed_transcript
  ENST00000428863 MDM2-203 68808191-68839849 protein_coding
  ENST00000462284 MDM2-204 68808172-68845544 protein_coding
  ENST00000471946 MDM2-014 68813602-68820414 retained_intron
  ENST00000478070 MDM2-011 68809227-68839849 protein_coding
  ENST00000481186 MDM2-007 68809212-68839849 nonsense_mediated_decay
  ENST00000493419 MDM2-015 68808282-68817018 retained_intron
  ENST00000496959 MDM2-005 68809212-68839849 nonsense_mediated_decay
  ENST00000517852 MDM2-019 68809212-68839849 protein_coding
  ENST00000523991 MDM2-016 68809017-68839314 protein_coding
  ENST00000536089 MDM2-031 68809212-68839849 nonsense_mediated_decay
  ENST00000537182 MDM2-030 68809212-68839849 nonsense_mediated_decay
  ENST00000539479 MDM2-012 68809017-68835933 protein_coding
  ENST00000540352 MDM2-028 68809212-68839849 nonsense_mediated_decay
  ENST00000540709 MDM2-042 68842441-68844181 processed_transcript
  ENST00000542502 MDM2-029 68809212-68839849 nonsense_mediated_decay
  ENST00000543046 MDM2-041 68824203-68824758 retained_intron
  ENST00000543323 MDM2-023 68809017-68839314 protein_coding
  ENST00000544125 MDM2-043 68843066-68844190 processed_transcript
  ENST00000544561 MDM2-026 68809212-68839791 protein_coding
  ENST00000545204 MDM2-024 68809212-68839849 protein_coding
  ENST00000546048 MDM2-027 68809212-68839849 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000258149ENST00000311420ENST00000350057ENST00000356290ENST00000462284ENST00000540709
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000258149 1.979±0.00 1.575±0.00 1.390±0.28 N/A 1.249±0.00 1.010±0.00 2.827±0.00 1.156±0.00 1.685±0.35 1.654±0.00 1.411±0.00 N/A 1.052±0.00
ENST00000311420 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.285±0.00 N/A N/A N/A
ENST00000350057 N/A N/A 8.350±0.00 17.411±0.00 9.246±0.00 3.272±0.00 12.336±0.00 17.562±0.00 13.737±0.00 N/A 17.972±0.00 N/A N/A
ENST00000356290 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.135±0.00 N/A N/A
ENST00000462284 N/A N/A 2.666±0.00 4.253±0.00 2.099±0.35 1.253±0.00 4.156±0.39 6.028±0.00 3.865±0.00 1.854±0.41 4.575±1.65 7.948±0.00 2.959±1.48
ENST00000540709 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 70.291±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002KM CIL_0002KM_0002 CGP 12:68746106-68850686

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0002039 IPI p53 binding
GO:0004842 IMP ubiquitin-protein transferase activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IMP cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006461 IDA protein complex assembly
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089 IEA traversing start control point of mitotic cell cycle
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0008270 IEA zinc ion binding
GO:0008284 TAS positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009636 IEA response to toxic substance
GO:0009743 IEA response to carbohydrate
GO:0010039 IEA response to iron ion
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010955 IEA negative regulation of protein processing
GO:0016032 IEA viral process
GO:0016567 IEA protein ubiquitination
GO:0016604 IDA nuclear body
GO:0016874 IEA ligase activity
GO:0018205 IMP peptidyl-lysine modification
GO:0019899 IPI enzyme binding
GO:0030163 IEA protein catabolic process
GO:0030666 TAS endocytic vesicle membrane
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031648 IDA protein destabilization
GO:0032026 IEA response to magnesium ion
GO:0032436 IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 IDA protein localization to nucleus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042176 IDA regulation of protein catabolic process
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0042787 IMP:IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IPI identical protein binding
GO:0042975 IEA peroxisome proliferator activated receptor binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043234 IDA protein complex
GO:0043278 IEA response to morphine
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 TAS innate immune response
GO:0045184 IDA establishment of protein localization
GO:0045202 IEA synapse
GO:0045472 IEA response to ether
GO:0045787 IEA positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0046677 IEP response to antibiotic
GO:0046827 IEA positive regulation of protein export from nucleus
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048545 IEA response to steroid hormone
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071157 IEA negative regulation of cell cycle arrest
GO:0071229 IEA cellular response to acid
GO:0071236 IEA cellular response to antibiotic
GO:0071301 IEA cellular response to vitamin B1
GO:0071310 IEA cellular response to organic substance
GO:0071312 IEA cellular response to alkaloid
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071391 IEA cellular response to estrogen stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071456 IEP cellular response to hypoxia
GO:0071494 IEA cellular response to UV-C
GO:0097110 IEA scaffold protein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033443 mdm2 transformed 3T3 cell double minute 2 homolog (mouse) protein_coding Danio_rerio
ENSMUSG00000020184 Mdm2 transformed mouse 3T3 cell double minute 2 protein_coding Mus_musculus

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