C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: legumain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021190 Lgmn 10090 - 12:102394084-102439813 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021607 Lgmn-001 102394098-102439813 protein_coding
  ENSMUST00000110020 Lgmn-002 102394084-102423769 protein_coding
  ENSMUST00000146499 Lgmn-003 102400102-102406146 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021607ENSMUST00000110020
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021607 53.049±4.58 79.751±5.97 26.085±3.53 16.052±1.81 49.655±5.36 52.146±5.99 29.997±5.66 159.398±26.27 27.816±9.69 63.180±5.14 9.039±1.46 153.977±58.09 54.035±24.36 13.831±5.95
ENSMUST00000110020 N/A N/A 4.810±0.00 17.431±13.95 52.880±0.00 N/A N/A 341.611±4.95 6.848±0.65 N/A 3.327±0.92 131.542±27.05 115.559±47.57 5.281±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000536 CIL_000536_0002 CGP 12:102283048-102439813
CIL_000537 CIL_000537_0002 CGP 12:102394084-102497902

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003014 IMP renal system process
GO:0004197 IDA cysteine-type endopeptidase activity
GO:0005764 IDA lysosome
GO:0005770 IDA late endosome
GO:0006508 IDA proteolysis
GO:0008233 IMP peptidase activity
GO:0010447 IMP response to acidic pH
GO:0032801 IMP receptor catabolic process
GO:0040015 IMP negative regulation of multicellular organism growth
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045177 IDA apical part of cell
GO:0051603 IMP proteolysis involved in cellular protein catabolic process
GO:0070062 IEA extracellular vesicular exosome
GO:1901185 IMP negative regulation of ERBB signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039150 lgmn legumain protein_coding Danio_rerio
ENSG00000100600 LGMN legumain protein_coding Homo_sapiens

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