C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: legumain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100600 LGMN 9606 - 14:92703807-92748702 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000334869 LGMN-001 92703809-92748702 protein_coding
  ENST00000393218 LGMN-005 92703844-92748679 protein_coding
  ENST00000553371 LGMN-009 92718811-92748627 protein_coding
  ENST00000553802 LGMN-012 92714424-92748627 protein_coding
  ENST00000553918 LGMN-018 92732728-92748570 protein_coding
  ENST00000554080 LGMN-010 92718810-92748627 protein_coding
  ENST00000554189 LGMN-013 92713852-92748627 nonsense_mediated_decay
  ENST00000554397 LGMN-011 92718747-92748627 protein_coding
  ENST00000554919 LGMN-015 92718747-92748627 protein_coding
  ENST00000555169 LGMN-020 92703822-92717459 protein_coding
  ENST00000555699 LGMN-004 92703807-92748612 protein_coding
  ENST00000556097 LGMN-019 92711659-92748612 nonsense_mediated_decay
  ENST00000556790 LGMN-021 92704276-92704905 retained_intron
  ENST00000557034 LGMN-014 92741433-92748626 processed_transcript
  ENST00000557315 LGMN-016 92732396-92748624 retained_intron
  ENST00000557434 LGMN-002 92703839-92748645 protein_coding
  ENST00000557609 LGMN-007 92703847-92748603 nonsense_mediated_decay
  ENST00000557694 LGMN-017 92715744-92748612 retained_intron
  ENST00000557725 LGMN-022 92706353-92712834 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000334869ENST00000393218ENST00000555169ENST00000555699ENST00000557434ENST00000557609ENST00000557725
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000334869 26.328±0.00 42.296±0.00 3.493±0.00 17.463±0.00 75.645±0.00 13.992±0.00 21.849±19.70 50.596±44.75 18.882±13.06 58.910±0.00 9.662±7.41 46.612±2.09 136.375±63.73 28.197±0.00
ENST00000393218 N/A N/A N/A N/A 4.333±0.00 8.534±0.00 1.079±0.00 N/A 4.131±0.00 2.525±0.00 N/A 8.349±4.06 N/A 6.923±0.00
ENST00000555169 N/A 35.817±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000555699 N/A N/A 2.996±0.00 4.681±0.00 N/A 1.963±0.00 2.894±0.00 7.882±0.00 N/A 6.394±0.00 1.048±0.00 1.541±0.00 N/A N/A
ENST00000557434 N/A N/A N/A N/A 11.321±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000557609 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 28.834±0.00 172.243±0.00 6.862±0.00
ENST00000557725 N/A N/A 15.814±0.00 N/A 15.202±0.00 6.956±0.00 N/A N/A N/A N/A N/A N/A 136.431±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000536 CIL_000536_0001 CGP 14:92513774-92748702
CIL_000537 CIL_000537_0001 CGP 14:92703807-92839963

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0003014 ISS renal system process
GO:0004197 ISS:IEA cysteine-type endopeptidase activity
GO:0005764 ISS lysosome
GO:0005770 IEA late endosome
GO:0006508 ISS:IEA proteolysis
GO:0008202 TAS steroid metabolic process
GO:0008233 IDA peptidase activity
GO:0010447 IEA response to acidic pH
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032801 ISS receptor catabolic process
GO:0040015 IEA negative regulation of multicellular organism growth
GO:0042359 TAS vitamin D metabolic process
GO:0043202 TAS lysosomal lumen
GO:0043524 IGI negative regulation of neuron apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045177 IEA apical part of cell
GO:0051603 ISS proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:1901185 ISS negative regulation of ERBB signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039150 lgmn legumain protein_coding Danio_rerio
ENSMUSG00000021190 Lgmn legumain protein_coding Mus_musculus

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