C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021451 Sema4d 10090 - 13:51701246-51793747 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021900 Sema4d-002 51701246-51793747 protein_coding
  ENSMUST00000110039 Sema4d-003 51701250-51734763 protein_coding
  ENSMUST00000110040 Sema4d-001 51701246-51793673 protein_coding
  ENSMUST00000125511 Sema4d-004 51711500-51714159 retained_intron
  ENSMUST00000138228 Sema4d-006 51723656-51748815 processed_transcript
  ENSMUST00000139018 Sema4d-010 51725271-51754765 processed_transcript
  ENSMUST00000139858 Sema4d-012 51725390-51777111 processed_transcript
  ENSMUST00000139865 Sema4d-005 51723656-51748919 processed_transcript
  ENSMUST00000143396 Sema4d-007 51725341-51748726 processed_transcript
  ENSMUST00000146238 Sema4d-008 51725291-51756802 processed_transcript
  ENSMUST00000146922 Sema4d-009 51725314-51756668 processed_transcript
  ENSMUST00000150662 Sema4d-011 51725224-51752165 processed_transcript
  ENSMUST00000155896 Sema4d-013 51725423-51793664 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021900ENSMUST00000110039ENSMUST00000110040
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021900 2.512±2.30 3.353±0.72 1.904±0.04 5.629±1.74 11.877±4.74 6.683±0.67 1.705±0.42 20.408±3.88 1.810±1.59 6.183±0.47 N/A 4.087±1.93 7.222±3.90 0.419±0.10
ENSMUST00000110039 1.182±0.82 N/A 0.496±0.19 N/A N/A N/A N/A N/A 0.324±0.22 1.874±0.35 N/A 0.982±0.25 N/A N/A
ENSMUST00000110040 0.699±0.53 0.466±0.05 0.356±0.07 0.864±0.21 3.916±1.11 1.282±0.25 N/A 5.242±1.22 0.465±0.25 N/A 2.867±0.00 1.149±0.28 2.421±0.83 0.137±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008UF CIL_0008UF_0002 VISTA 13:51620205-52221621
CIL_0006BJ CIL_0006BJ_0002 CGP 13:51701246-51848468

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0004888 ISS transmembrane signaling receptor activity
GO:0005102 IPI receptor binding
GO:0005615 IDA extracellular space
GO:0005887 IEA integral component of plasma membrane
GO:0007162 ISS negative regulation of cell adhesion
GO:0008360 ISS regulation of cell shape
GO:0010693 IDA negative regulation of alkaline phosphatase activity
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 TAS membrane
GO:0030215 IPI semaphorin receptor binding
GO:0030335 IDA positive regulation of cell migration
GO:0031344 ISS regulation of cell projection organization
GO:0032321 IMP positive regulation of Rho GTPase activity
GO:0043931 IMP ossification involved in bone maturation
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0048672 ISS positive regulation of collateral sprouting
GO:0048814 ISS regulation of dendrite morphogenesis
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 IDA negative regulation of peptidyl-tyrosine phosphorylation
GO:0050772 IDA positive regulation of axonogenesis
GO:0070486 ISS leukocyte aggregation
GO:0071526 ISS semaphorin-plexin signaling pathway
GO:1900220 IMP semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000067801 SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D protein_coding Danio_rerio
ENSG00000187764 SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D protein_coding Homo_sapiens

Loading