C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000021900 Sema4d-002 ENSMUSG00000021451 10090 - 13:51701246-51793747 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000021900
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000021900 2.512±2.30 3.353±0.72 1.904±0.04 5.629±1.74 11.877±4.74 6.683±0.67 1.705±0.42 20.408±3.88 1.810±1.59 6.183±0.47 4.087±1.93 7.222±3.90 0.419±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008UF CIL_0008UF_0002 VISTA 13:51620205-52221621
CIL_0006BJ CIL_0006BJ_0002 CGP 13:51701246-51848468

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0004888 ISS transmembrane signaling receptor activity
GO:0005102 IPI receptor binding
GO:0005615 IDA extracellular space
GO:0005887 IEA integral component of plasma membrane
GO:0007162 ISS negative regulation of cell adhesion
GO:0008360 ISS regulation of cell shape
GO:0010693 IDA negative regulation of alkaline phosphatase activity
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 TAS membrane
GO:0030215 IPI semaphorin receptor binding
GO:0030335 IDA positive regulation of cell migration
GO:0031344 ISS regulation of cell projection organization
GO:0032321 IMP positive regulation of Rho GTPase activity
GO:0043931 IMP ossification involved in bone maturation
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0048672 ISS positive regulation of collateral sprouting
GO:0048814 ISS regulation of dendrite morphogenesis
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 IDA negative regulation of peptidyl-tyrosine phosphorylation
GO:0050772 IDA positive regulation of axonogenesis
GO:0070486 ISS leukocyte aggregation
GO:0071526 ISS semaphorin-plexin signaling pathway
GO:1900220 IMP semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000356444 SEMA4D-201 protein_coding Homo_sapiens 0 2340
ENST00000422704 SEMA4D-005 protein_coding Homo_sapiens 0 2340
ENST00000438547 SEMA4D-004 protein_coding Homo_sapiens 0 2340
ENST00000450295 SEMA4D-018 protein_coding Homo_sapiens 0 2340

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