C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 4D, cAMP specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021699 Pde4d 10090 + 13:108449948-109953461 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000074103 Pde4d-009 109686156-109951474 protein_coding
  ENSMUST00000079975 Pde4d-019 109581405-109951344 protein_coding
  ENSMUST00000117420 Pde4d-014 109926844-109951364 protein_coding
  ENSMUST00000117879 Pde4d-013 109925063-109951344 protein_coding
  ENSMUST00000119507 Pde4d-007 109442183-109951364 protein_coding
  ENSMUST00000119672 Pde4d-012 109903102-109951387 nonsense_mediated_decay
  ENSMUST00000120664 Pde4d-011 109903106-109953461 protein_coding
  ENSMUST00000120671 Pde4d-003 109116641-109951387 protein_coding
  ENSMUST00000122041 Pde4d-001 108654177-109951474 protein_coding
  ENSMUST00000129374 Pde4d-006 109116236-109335063 processed_transcript
  ENSMUST00000133929 Pde4d-002 108449948-108861128 processed_transcript
  ENSMUST00000134973 Pde4d-010 109686176-109773438 retained_intron
  ENSMUST00000135275 Pde4d-008 109632780-109951364 protein_coding
  ENSMUST00000138938 Pde4d-004 109116359-109773441 retained_intron
  ENSMUST00000151111 Pde4d-015 108450009-108860143 processed_transcript
  ENSMUST00000151429 Pde4d-017 109922911-109938282 retained_intron
  ENSMUST00000152630 Pde4d-016 109757221-109761612 processed_transcript
  ENSMUST00000153234 Pde4d-005 109260654-109951364 protein_coding
  ENSMUST00000155459 Pde4d-018 109935312-109948348 protein_coding
  ENSMUST00000177907 Pde4d-201 108860166-109951344 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000074103ENSMUST00000079975ENSMUST00000119507ENSMUST00000119672ENSMUST00000120664ENSMUST00000122041ENSMUST00000134973ENSMUST00000135275ENSMUST00000153234ENSMUST00000177907
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000074103 N/A N/A N/A 2.078±0.00 3.159±0.00 N/A 3.098±0.00 N/A N/A 1.939±0.77 0.988±0.00 N/A
ENSMUST00000079975 N/A N/A N/A N/A N/A N/A 0.935±0.18 N/A N/A 1.370±0.44 N/A 0.167±0.00
ENSMUST00000119507 N/A 1.508±0.19 8.034±3.95 3.016±0.00 4.702±0.79 4.701±1.36 N/A 1.785±0.00 N/A 1.415±0.29 N/A 0.315±0.00
ENSMUST00000119672 N/A 0.989±0.23 N/A 2.541±0.59 N/A N/A N/A N/A N/A N/A 0.992±0.00 N/A
ENSMUST00000120664 N/A 0.883±0.66 6.525±4.53 1.665±0.06 1.129±0.08 1.494±0.00 0.247±0.09 1.001±0.00 4.344±0.00 0.668±0.23 N/A 0.349±0.15
ENSMUST00000122041 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.304±0.02
ENSMUST00000134973 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.705±0.00 N/A N/A
ENSMUST00000135275 3.169±0.67 1.267±0.54 N/A 2.187±0.00 N/A N/A 1.473±1.08 2.814±0.81 N/A 1.550±0.37 0.603±0.00 0.294±0.00
ENSMUST00000153234 2.015±0.24 N/A N/A N/A 1.557±0.06 1.724±0.00 N/A N/A N/A 0.969±0.04 1.627±0.00 0.240±0.00
ENSMUST00000177907 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.293±0.02

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002027 IMP regulation of heart rate
GO:0004112 IEA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IDA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IEA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005813 IEA centrosome
GO:0005829 IEA cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005891 IDA voltage-gated calcium channel complex
GO:0006198 IEA cAMP catabolic process
GO:0006939 IMP smooth muscle contraction
GO:0007165 IEA signal transduction
GO:0007568 IMP aging
GO:0007613 IEA memory
GO:0008144 IEA drug binding
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0010469 IEA regulation of receptor activity
GO:0010738 IEA regulation of protein kinase A signaling
GO:0010880 IMP regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0017124 IEA SH3 domain binding
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030016 IEA myofibril
GO:0030324 IEA lung development
GO:0030552 IEA cAMP binding
GO:0030593 IMP neutrophil chemotaxis
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031698 IEA beta-2 adrenergic receptor binding
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032743 IEA positive regulation of interleukin-2 production
GO:0032754 IEA positive regulation of interleukin-5 production
GO:0033137 IMP negative regulation of peptidyl-serine phosphorylation
GO:0034704 IDA calcium channel complex
GO:0035264 IMP multicellular organism growth
GO:0043623 IEA cellular protein complex assembly
GO:0044325 IPI ion channel binding
GO:0045822 IMP negative regulation of heart contraction
GO:0046872 IEA metal ion binding
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050852 IEA T cell receptor signaling pathway
GO:0050900 IMP leukocyte migration
GO:0051117 IPI ATPase binding
GO:0060314 IMP regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 ISS establishment of endothelial barrier
GO:0071222 IMP cellular response to lipopolysaccharide
GO:0071320 IEA cellular response to cAMP
GO:0071872 IMP cellular response to epinephrine stimulus
GO:0071875 IEA adrenergic receptor signaling pathway
GO:0086004 IMP regulation of cardiac muscle cell contraction
GO:0097110 IEA scaffold protein binding
GO:1901844 IC regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 IMP negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032761 pde4d phosphodiesterase 4D, cAMP-specific protein_coding Danio_rerio
ENSG00000113448 PDE4D phosphodiesterase 4D, cAMP-specific protein_coding Homo_sapiens

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