C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphodiesterase 4D, cAMP specific
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000122041 Pde4d-001 ENSMUSG00000021699 10090 + 13:108654177-109951474 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; TestisENSMUST00000122041
Transcript ID Testis
ENSMUST00000122041 0.304±0.02

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002027 IMP regulation of heart rate
GO:0004112 IEA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IDA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IEA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005813 IEA centrosome
GO:0005829 IEA cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005891 IDA voltage-gated calcium channel complex
GO:0006198 IEA cAMP catabolic process
GO:0006939 IMP smooth muscle contraction
GO:0007165 IEA signal transduction
GO:0007568 IMP aging
GO:0007613 IEA memory
GO:0008144 IEA drug binding
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0010469 IEA regulation of receptor activity
GO:0010738 IEA regulation of protein kinase A signaling
GO:0010880 IMP regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0017124 IEA SH3 domain binding
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030016 IEA myofibril
GO:0030324 IEA lung development
GO:0030552 IEA cAMP binding
GO:0030593 IMP neutrophil chemotaxis
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031698 IEA beta-2 adrenergic receptor binding
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032743 IEA positive regulation of interleukin-2 production
GO:0032754 IEA positive regulation of interleukin-5 production
GO:0033137 IMP negative regulation of peptidyl-serine phosphorylation
GO:0034704 IDA calcium channel complex
GO:0035264 IMP multicellular organism growth
GO:0043623 IEA cellular protein complex assembly
GO:0044325 IPI ion channel binding
GO:0045822 IMP negative regulation of heart contraction
GO:0046872 IEA metal ion binding
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050852 IEA T cell receptor signaling pathway
GO:0050900 IMP leukocyte migration
GO:0051117 IPI ATPase binding
GO:0060314 IMP regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 ISS establishment of endothelial barrier
GO:0071222 IMP cellular response to lipopolysaccharide
GO:0071320 IEA cellular response to cAMP
GO:0071872 IMP cellular response to epinephrine stimulus
GO:0071875 IEA adrenergic receptor signaling pathway
GO:0086004 IMP regulation of cardiac muscle cell contraction
GO:0097110 IEA scaffold protein binding
GO:1901844 IC regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 IMP negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000002096 pde4ca-201 protein_coding Danio_rerio 0 797
ENSDART00000141030 pde4ca-001 protein_coding Danio_rerio 0 797
ENST00000309641 PDE4D-013 nonsense_mediated_decay Homo_sapiens 0 1790
ENST00000317118 PDE4D-020 protein_coding Homo_sapiens 0 1905
ENST00000340635 PDE4D-001 protein_coding Homo_sapiens 0 2625
ENST00000358923 PDE4D-019 protein_coding Homo_sapiens 0 2104
ENST00000360047 PDE4D-014 protein_coding Homo_sapiens 0 2623
ENST00000405053 PDE4D-002 processed_transcript Homo_sapiens 0 521
ENST00000405755 PDE4D-015 protein_coding Homo_sapiens 0 2614
ENST00000502484 PDE4D-003 protein_coding Homo_sapiens 0 2839
ENST00000502575 PDE4D-011 protein_coding Homo_sapiens 0 521
ENST00000503258 PDE4D-016 protein_coding Homo_sapiens 0 2617
ENST00000505453 PDE4D-017 protein_coding Homo_sapiens 0 1792
ENST00000505507 PDE4D-009 protein_coding Homo_sapiens 0 233
ENST00000506024 PDE4D-008 retained_intron Homo_sapiens 0 254
ENST00000506510 PDE4D-006 retained_intron Homo_sapiens 0 254
ENST00000507116 PDE4D-012 protein_coding Homo_sapiens 0 2623
ENST00000509355 PDE4D-004 retained_intron Homo_sapiens 0 254
ENST00000511382 PDE4D-007 retained_intron Homo_sapiens 0 254
ENST00000514231 PDE4D-025 retained_intron Homo_sapiens 0 291
ENST00000514552 PDE4D-021 protein_coding Homo_sapiens 0 220
ENST00000515011 PDE4D-018 retained_intron Homo_sapiens 0 2073
ENST00000515324 PDE4D-024 processed_transcript Homo_sapiens 0 470
ENST00000546160 PDE4D-201 protein_coding Homo_sapiens 0 2623
ENST00000621323 PDE4D-026 processed_transcript Homo_sapiens 0 520

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