C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin 6 signal transducer
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000183663 Il6st-001 ENSMUSG00000021756 10090 + 13:112464070-112510086 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000183663
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000183663 16.477±7.22 4.166±0.00 14.208±1.69 3.003±0.63 6.324±3.31 3.361±1.07 3.495±0.48 10.572±1.06 3.907±2.67 11.462±0.43 2.906±0.21 8.783±3.67 7.141±3.96 0.895±0.13

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004897 IEA ciliary neurotrophic factor receptor activity
GO:0004915 IEA interleukin-6 receptor activity
GO:0004921 IDA interleukin-11 receptor activity
GO:0004923 IEA leukemia inhibitory factor receptor activity
GO:0004924 IEA oncostatin-M receptor activity
GO:0005127 IEA ciliary neurotrophic factor receptor binding
GO:0005138 IEA interleukin-6 receptor binding
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005896 IEA interleukin-6 receptor complex
GO:0005900 IEA oncostatin-M receptor complex
GO:0005977 IMP glycogen metabolic process
GO:0007165 IDA signal transduction
GO:0008284 IGI positive regulation of cell proliferation
GO:0008593 IDA regulation of Notch signaling pathway
GO:0009897 IDA external side of plasma membrane
GO:0016020 IEA membrane
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019838 IEA growth factor binding
GO:0019970 IDA interleukin-11 binding
GO:0019981 IEA interleukin-6 binding
GO:0030425 IDA dendrite
GO:0034097 IEA response to cytokine
GO:0038154 IDA interleukin-11-mediated signaling pathway
GO:0038165 IEA oncostatin-M-mediated signaling pathway
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042511 IEA positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IEA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043025 IDA neuronal cell body
GO:0044297 IDA cell body
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0048711 IMP positive regulation of astrocyte differentiation
GO:0048861 IEA leukemia inhibitory factor signaling pathway
GO:0070062 IEA extracellular vesicular exosome
GO:0070102 IEA interleukin-6-mediated signaling pathway
GO:0070104 IEA negative regulation of interleukin-6-mediated signaling pathway
GO:0070106 IEA interleukin-27-mediated signaling pathway
GO:0070110 IEA ciliary neurotrophic factor receptor complex
GO:0070120 IEA ciliary neurotrophic factor-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000336909 IL6ST-201 protein_coding Homo_sapiens 0 1962
ENST00000346911 IL6STP1-001 processed_pseudogene Homo_sapiens 0 329
ENST00000381286 IL6ST-005 protein_coding Homo_sapiens 0 204
ENST00000381287 IL6ST-202 protein_coding Homo_sapiens 0 1399
ENST00000381293 IL6ST-003 protein_coding Homo_sapiens 0 206
ENST00000381294 IL6ST-012 protein_coding Homo_sapiens 0 1116
ENST00000381298 IL6ST-001 protein_coding Homo_sapiens 0 1962
ENST00000502326 IL6ST-011 protein_coding Homo_sapiens 0 1881
ENST00000503773 IL6ST-006 nonsense_mediated_decay Homo_sapiens 0 1367
ENST00000522633 IL6ST-007 protein_coding Homo_sapiens 0 516
ENST00000523039 IL6ST-010 retained_intron Homo_sapiens 0 499
ENST00000583149 IL6ST-013 retained_intron Homo_sapiens 0 538

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